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Mar 21, 2026 2:45 PM EDT
MSU
-4½ (-115)o151½ (-110)
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Louisville Cardinals vs Michigan State Spartans Betting Trends
Updated:Mar 21, 2026 2:23 AM EDT
The upcoming NCAAB matchup on March 21, 2026, features the Louisville Cardinals visiting the Michigan State Spartans at KeyBank Center in Buffalo, NY. Broadcasted on CBS, this game offers critical betting trends and game insights. Michigan State holds a 26-7 overall record with a strong 19-3 home record, while Louisville stands at 24-10 with a 7-8 away record. The Spartans average 79.3 points per game with a 36.3% 3-point shooting percentage, slightly edging Louisville's 84.7 points and 36.1% from beyond the arc. The spread is set at Michigan State -4.5 with a total of 151.5 points, reflecting expectations of a competitive contest. Notably, both teams have key starters probable despite some questionable injury statuses, which could impact game dynamics and betting stats. Recent performances indicate Michigan State's defensive rating at 102.3 aligns closely with Louisville's 103.0, suggesting a balanced defensive battle. The teams last met in December 2021, where Michigan State prevailed 73-64, an encounter detailed further in their last matchup.
ATS Records
All
16-18 (215th)Against the Spread16-16-1 (186th)
6-9Home / Away10-12
24-10 (49th)Straight Up26-7 (29th)
7-8Home / Away19-3
-4.9Straight Up Units+2.1
-5.1Home / Away+0.9
15-19Over / Under16-17
8-7Home / Away10-12
TEAM MATCHUP
84.7Points79.3
28.7Field Goals Made27.7
60.8Field Goals Attempted58.5
47%Field Goal Percentage47%
11.63 Point Field Goals Made7.7
32.13 Point Field Goals Attempted21.3
36%3 Point Field Goal Percentage36%
15.7Free Throws Made16.2
20.6Free Throws Attempted21.1
76%Free Throw Percentage76%
36.2Rebounds36.8
10.1Offensive Rebounds10.9
26.1Defensive Rebounds25.9
17.1Assists18.7
11.6Turnovers10.9
6.8Steals5.1
3.3Blocks4.2
18.4Personal Fouls16.2
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Live college basketball odds are always available at OddsTrader. You can keep up with your favorite teams or consider using our stats-driven NCAAB computer picks to help you make smarter wagers. Betting action intensifies during March Madness, making it crucial to track odds and betting lines in real time. New bettors can read on to learn more about NCAAB odds.
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NCAAB - March MadnessSat 03/21
 #3Michigan 32-364% -12½ -106Bookmaker | |||||||
 #11Michigan State 26-725% -4½ -108Heritage | |||||||
 #1Duke 33-250% -11½ -108Heritage | |||||||
 #5Houston 29-650% -10½ -108Heritage | |||||||
 #12Gonzaga 31-357% -6 -115Bookmaker | |||||||
 #13Illinois 25-825% -11 -108Heritage | |||||||
 #15Nebraska 27-667% +2 -113Bet105 | |||||||
 #14Arkansas 27-80% -11½ -108Heritage | |||||||
 #8Purdue 28-8- -7½ -108Bookmaker | |||||||
 #6Iowa State 28-70% -4½ -110Everygame | |||||||
 #17Kansas 24-10- +3½ -108Heritage | |||||||
 #9Virginia 30-533% +1½ -110BetAnything | |||||||
 #2Arizona 33-20% -11½ -108Heritage | |||||||
 #7Connecticut 30-5- -4 -108Heritage | |||||||
 #18Alabama 24-9100% PK -108Heritage |
NCAAB - NITSat 03/21
 NC-Wilmington 27-6100% +2½ -108Heritage | |||||||
 Nevada 23-12100% -7 -110BetOnline | |||||||
 Wake Forest 18-16- -7½ -108Heritage | |||||||
 Auburn 18-16- -13½ -108Bet105 | |||||||
 Tulsa 27-7- -4 -117Bookmaker | |||||||
 #4Florida 27-7- -10 -110BetAnything | |||||||
 New Mexico 24-10- -7½ -108Heritage | |||||||
 Oklahoma State 20-14- -3½ -108BetOnline | |||||||
 California 22-11- -5½ -110Bookmaker |
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