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Mar 21, 2026 2:45 PM EDT
MSU
-4½ (-115)o151½ (-110)
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Louisville Cardinals vs Michigan State Spartans Picks
Updated:Mar 21, 2026 2:24 AM EDT
The upcoming NCAAB matchup between the Louisville Cardinals and Michigan State Spartans is scheduled for March 21, 2026, at 2:45 PM ET. The game will be held at KeyBank Center in Buffalo, NY, and broadcast on CBS. Our picks favor Michigan State with a predicted score of 77-73 and a -4.5 point spread, reflecting a 51.2% coverage rate and an EV of -0.7%. Recent prediction models have been profitable, especially on the point spread market, with a notable hit rate in the last 10 games. For deeper analysis, visit our NCAAB picks page.
UPCOMING GAME PREDICTION
Spread
Money
Total
MSUSpread
CONSENSUS LINE
-4½ (-115)
PROJECTION
MSU (77) - LOU (73)
COVER PROBABILITY
EXPECTED VALUE
-0.7%
BET RATING
SEASON COVER %
16/33
48%
NCAAB
Live college basketball odds are always available at OddsTrader. You can keep up with your favorite teams or consider using our stats-driven NCAAB computer picks to help you make smarter wagers. Betting action intensifies during March Madness, making it crucial to track odds and betting lines in real time. New bettors can read on to learn more about NCAAB odds.
Spread
Game
- Game
- 1H
- 2H
DIV 1
Top 25
DIV 1
ACC
BIG10
BIG12
SEC
A10
AAC
AE
AS
BIGEAST
BIGSKY
BIGSOUTH
BIGWEST
CUSA
HORIZON
IVY
MAAC
MAC
MEAC
MVC
MWC
NE
OVC
PATRIOT
SOUTHERN
SOUTHLAND
SUMMIT
SUNBELT
SWAC
WAC
WCC
NCAAB - March MadnessSat 03/21
 #3Michigan 32-364% -12½ -106Bookmaker | |||||||
 #11Michigan State 26-725% -4½ -108Heritage | |||||||
 #1Duke 33-250% -11½ -108Heritage | |||||||
 #5Houston 29-650% -10½ -108Heritage | |||||||
 #12Gonzaga 31-357% -6 -115Bookmaker | |||||||
 #13Illinois 25-825% -11 -108Heritage | |||||||
 #15Nebraska 27-667% +2 -113Bet105 | |||||||
 #14Arkansas 27-80% -11½ -108Heritage | |||||||
 #8Purdue 28-8- -7½ -108Bookmaker | |||||||
 #6Iowa State 28-70% -4½ -110Everygame | |||||||
 #17Kansas 24-10- +3½ -108Heritage | |||||||
 #9Virginia 30-533% +1½ -110BetAnything | |||||||
 #2Arizona 33-20% -11½ -108Heritage | |||||||
 #7Connecticut 30-5- -4 -108Heritage | |||||||
 #18Alabama 24-9100% PK -108Heritage |
NCAAB - NITSat 03/21
 NC-Wilmington 27-6100% +2½ -108Heritage | |||||||
 Nevada 23-12100% -7 -110BetOnline | |||||||
 Wake Forest 18-16- -7½ -108Heritage | |||||||
 Tulsa 27-7- -4 -117Bookmaker | |||||||
 #4Florida 27-7- -10 -110BetAnything | |||||||
 New Mexico 24-10- -7½ -108Heritage | |||||||
 Oklahoma State 20-14- -3½ -108BetOnline | |||||||
 California 22-11- -5½ -110Bookmaker |
NCAAB - Extra GamesSun 03/22
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