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Mar 21, 2026 2:45 PM EDT
MSU
-4½ (-115)o151½ (-110)
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Louisville Cardinals vs Michigan State Spartans Odds
Updated:Mar 21, 2026 2:26 AM EDT
The Louisville Cardinals visit the Michigan State Spartans on March 21, 2026, at KeyBank Center in Buffalo, NY for an NCAAB regular season game broadcast on CBS. Current odds favor Michigan State with a -4½ -115 point spread, a shift from an opening -5 -110, reflecting increased confidence in the Spartans. Louisville holds +4½ -105. The total points line stands at 151½ with over -115 and under -105 odds. These betting lines provide insights into market expectations for this matchup. For additional details, see the NCAAB odds page.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
LouisvilleSpread
-3.6%
EV
-3.6%
Michigan StateSpread
-0.7%
EV
-0.7%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
LouisvilleMONEYLINE
-1.4%
EV
-1.4%
Michigan StateMONEYLINE
-0.9%
EV
-0.9%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-4.9%
EV
-4.9%
UNDERTotal
+1.3%
EV
+1.3%
Spread (1H)
BEST LINE
LouisvilleSpread
Michigan StateSpread
MONEYLINE (1H)
BEST LINE
LouisvilleMONEYLINE
Michigan StateMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
NCAAB
Live college basketball odds are always available at OddsTrader. You can keep up with your favorite teams or consider using our stats-driven NCAAB computer picks to help you make smarter wagers. Betting action intensifies during March Madness, making it crucial to track odds and betting lines in real time. New bettors can read on to learn more about NCAAB odds.
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DIV 1
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IVY
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NCAAB - March MadnessSat 03/21
 #3Michigan 32-364% -12½ -106Bookmaker | |||||||
 #11Michigan State 26-725% -4½ -108Heritage | |||||||
 #1Duke 33-250% -11½ -108Heritage | |||||||
 #5Houston 29-650% -10½ -108Heritage | |||||||
 #12Gonzaga 31-357% -6 -115Bookmaker | |||||||
 #13Illinois 25-825% -11 -108Heritage | |||||||
 #15Nebraska 27-667% +2 -113Bet105 | |||||||
 #14Arkansas 27-80% -11½ -108Heritage | |||||||
 #8Purdue 28-8- -7½ -108Bookmaker | |||||||
 #6Iowa State 28-70% -4½ -110Everygame | |||||||
 #17Kansas 24-10- +3½ -108Heritage | |||||||
 #9Virginia 30-533% +1½ -110BetAnything | |||||||
 #2Arizona 33-20% -11½ -108Heritage | |||||||
 #7Connecticut 30-5- -4 -108Heritage | |||||||
 #18Alabama 24-9100% PK -108Heritage |
NCAAB - NITSat 03/21
 NC-Wilmington 27-6100% +2½ -108Heritage | |||||||
 Nevada 23-12100% -7 -110BetOnline | |||||||
 Wake Forest 18-16- -7½ -108Heritage | |||||||
 Tulsa 27-7- -4 -117Bookmaker | |||||||
 #4Florida 27-7- -10 -110BetAnything | |||||||
 New Mexico 24-10- -7½ -108Heritage | |||||||
 Oklahoma State 20-14- -3½ -108BetOnline | |||||||
 California 22-11- -5½ -110Bookmaker |
NCAAB - Extra GamesSun 03/22
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