- Spread
- Money
- Total
- Merged
The Louisville Cardinals visit the Michigan State Spartans on March 21, 2026, at KeyBank Center in Buffalo, NY for an NCAAB regular season game broadcast on CBS. Current odds favor Michigan State with a -4½ -115 point spread, a shift from an opening -5 -110, reflecting increased confidence in the Spartans. Louisville holds +4½ -105. The total points line stands at 151½ with over -115 and under -105 odds. These betting lines provide insights into market expectations for this matchup. For additional details, see the NCAAB odds page.
Live college basketball odds are always available at OddsTrader. You can keep up with your favorite teams or consider using our stats-driven NCAAB computer picks to help you make smarter wagers. Betting action intensifies during March Madness, making it crucial to track odds and betting lines in real time. New bettors can read on to learn more about NCAAB odds.