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FINAL
Mar 21, 2026 2:48 PM EDT
LOU 69 vs MSU 77
MSU
-5 (-116)o151½ (-112)
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Louisville Cardinals vs Michigan State Spartans Picks
Updated:Mar 21, 2026 2:24 AM EDT
The upcoming NCAAB matchup between the Louisville Cardinals and Michigan State Spartans is scheduled for March 21, 2026, at 2:45 PM ET. The game will be held at KeyBank Center in Buffalo, NY, and broadcast on CBS. Our picks favor Michigan State with a predicted score of 77-73 and a -4.5 point spread, reflecting a 51.2% coverage rate and an EV of -0.7%. Recent prediction models have been profitable, especially on the point spread market, with a notable hit rate in the last 10 games. For deeper analysis, visit our NCAAB picks page.
UPCOMING GAME PREDICTION
Spread
Money
Total
MSUSpread
CONSENSUS LINE
-5 (-112)
PROJECTION
MSU (78) - LOU (73)
COVER PROBABILITY
EXPECTED VALUE
-0.1%
BET RATING
SEASON COVER %
16/33
48%
NCAAB
Live college basketball odds are always available at OddsTrader. You can keep up with your favorite teams or consider using our stats-driven NCAAB computer picks to help you make smarter wagers. Betting action intensifies during March Madness, making it crucial to track odds and betting lines in real time. New bettors can read on to learn more about NCAAB odds.
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