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Get ready for Saturday football as the Eastern Illinois Panthers vs Southeast Missouri State Redhawks meet on October 18, 2025 at Houck Field in Cape Girardeau, MO. Kickoff is set for 3pm ET on ESPN+.
Get the latest betting trends and game insights heading into this NCAAF clash. The Panthers’ passing attack averages 176 yards per game, facing a Redhawks defense allowing 274 yards through the air. Meanwhile, Southeast Missouri State throws for 260.7 yards per contest against a Panthers unit yielding 227.2 yards.
On the ground, Eastern Illinois churns out 165 rushing yards per outing into a Redhawks run defense giving up 201.8 yards. Conversely, SEMO averages just 111.3 yards on the ground while the Panthers concede 138.8 yards on average.
Look for heavy pressure in the trenches. Eastern Illinois allows 3.5 sacks per game against SEMO’s 2.17 sacks of their foes, while Redhawks give up 3.33 sacks versus Panthers forcing 2.17 sacks. That tug-of-war could decide the tempo.
The Panthers’ starting quarterback is unconfirmed, so expect their backup to be tested early. The Redhawks’ veteran QB has shown consistency. With no major injuries reported, both lineups are at full strength.
Currently the Redhawks are favored by 3 points with a 54-point total. Given Eastern Illinois’s 4-2 ATS record, grabbing the Panthers +3 looks smart. In their last matchup on October 5, 2024, Southeast Missouri State beat Eastern Illinois 38-27. For deeper ATS context, check our NCAAF standings page.
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Minnesota 4-230% +7½ -120FanDuel | |||||||
![]() Utah State 3-332% -3½ -122FanDuel | |||||||
![]() California 4-233% -8 -117BetRivers | |||||||
Miami (OH) 3-317% -12½ -115FanDuel | |||||||
![]() Boston College 1-571% -1½ -110Bet365 | |||||||
![]() Duke 4-277% -1 -114BetRivers | |||||||
Bowling Green 3-342% -3½ -110Caesars | |||||||
![]() #17Vanderbilt 5-150% -2½ -113BetRivers | |||||||
![]() Michigan 4-258% -4½ -110Caesars | |||||||
![]() Houston 5-144% +1½ -110BetMGM | |||||||
TCU 4-261% -2½ -122FanDuel | |||||||
![]() Tulane 5-118% -9½ -110Bet365 | |||||||
![]() South Carolina 3-369% +6 -117SugarHouse | |||||||
UCF 3-348% -7½ -105Bet365 | |||||||
![]() Toledo 3-340% -25½ -110BetMGM | |||||||
![]() Massachusetts 0-679% +16½ -105FanDuel | |||||||
![]() Louisiana-Monroe 3-369% +6 -110Caesars | |||||||
![]() Northwestern 4-243% -2½ -115FanDuel | |||||||
Appalachian State 4-20% -10 -110Bet365 | |||||||
![]() Ohio 3-37% -11 -110Caesars | |||||||
![]() James Madison 5-137% +1½ -118BetMGM | |||||||
![]() Charlotte 1-560% +11½ -110Caesars | |||||||
![]() Clemson 3-344% -5½ -110Caesars | |||||||
![]() #3Indiana 6-035% -26½ -120SugarHouse | |||||||
Marshall 3-361% +3 -114Caesars | |||||||
Ball State 2-414% -1 -110Caesars | |||||||
![]() Boise State 4-278% -12 -114BetRivers | |||||||
![]() North Texas 5-139% -3½ -115BetMGM | |||||||
![]() #9Georgia 5-169% -7½ -105Caesars | |||||||
![]() Arkansas 2-482% +8 -115SugarHouse | |||||||
![]() Wisconsin 2-493% +26 -113BetRivers | |||||||
Air Force 1-514% -4 -112Caesars | |||||||
UAB 2-417% +22½ -114BetRivers | |||||||
![]() Arizona State 4-240% +7½ -110BetMGM | |||||||
Florida 2-452% -8½ -114SugarHouse | |||||||
![]() Louisiana 2-482% +3½ -108FanDuel | |||||||
![]() #18Virginia 5-130% -17½ -110Caesars | |||||||
Rutgers 3-378% +17½ -112FanDuel | |||||||
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UCLA 2-445% -2½ -115Caesars | |||||||
Iowa 4-278% -2½ -118FanDuel | |||||||
Kentucky 2-373% +12½ -105BetMGM | |||||||
![]() #19South Florida 5-16% -21 -110Caesars | |||||||
Syracuse 3-347% +11 -115Bet365 | |||||||
#13Notre Dame 4-267% -9 -113SugarHouse | |||||||
#6Alabama 5-139% -8 -110Caesars | |||||||
Auburn 3-360% +2 -115SugarHouse | |||||||
Oklahoma State 1-582% +22 -112BetRivers | |||||||
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