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Get ready for some exciting Saturday football action on October 4, 2025, as the Eastern Illinois Panthers take on the Tennessee State Tigers at O'Brien Field in Charleston, IL. This NCAAF matchup promises to be a thrilling encounter, with the Panthers looking to capitalize on their home advantage. The game will be broadcast on ESPN+, so make sure you tune in for every play.
Our picks for this game favor the Panthers, given their recent form. They have a solid hit rate of 55.3% on the point spread, which suggests they might cover the spread against the Tigers. Our prediction model, which has been profitable in 6 of the last 10 games, sees Eastern Illinois winning with a predicted score of 27-21.
For those looking to place bets, consider the Over 61.5 market, which has a strong EV and a profitable history in recent matchups. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more detailed predictions and betting tips, check out our NCAAF picks page.
![]() South Florida 3-113% -28 -110Caesars | |||||||
![]() Delaware 3-150% -2½ -110Bet365 | |||||||
![]() San Jose State 1-354% -2½ -110Caesars | |||||||
#23Brigham Young 4-038% -18½ -118FanDuel | |||||||
San Diego State 3-129% -5½ -122FanDuel | |||||||
Navy 4-017% -12 -110Caesars | |||||||
![]() #12Georgia 3-128% -20½ -105FanDuel | |||||||
![]() Cincinnati 3-168% -1½ -110Caesars | |||||||
![]() #20Michigan 3-137% -17 -110Caesars | |||||||
![]() North Carolina 2-267% +14½ -105FanDuel | |||||||
![]() Pittsburgh 2-238% -6 -114SugarHouse | |||||||
Ball State 1-377% +14½ -108Caesars | |||||||
![]() Purdue 2-273% +9½ -104FanDuel | |||||||
Baylor 3-241% -5½ -118BetRivers | |||||||
UAB 2-237% +7½ -128FanDuel | |||||||
Temple 2-246% +6½ -106FanDuel | |||||||
Virginia Tech 2-342% -5½ -118BetMGM | |||||||
![]() North Carolina State 3-2- -42½ -110Bet365 | |||||||
![]() Massachusetts 0-485% +14 -118BetRivers | |||||||
![]() Arizona 3-127% -20½ -105FanDuel | |||||||
Appalachian State 2-227% -1½ -110Caesars | |||||||
Louisville 4-062% -6 -115BetRivers | |||||||
Maryland 4-042% +6½ -105FanDuel | |||||||
![]() Akron 1-465% +7½ -105BetMGM | |||||||
Buffalo 2-325% -9½ -118BetMGM | |||||||
Georgia State 1-379% +20½ -115BetMGM | |||||||
![]() Northwestern 2-255% -11½ -110Bet365 | |||||||
![]() Northern Illinois 1-372% +5½ -114SugarHouse | |||||||
UCLA 0-473% +25 -114BetRivers | |||||||
Florida 1-367% +6 -115SugarHouse | |||||||
#10Alabama 3-142% -10½ -110Caesars | |||||||
SMU 2-252% -17½ -105BetMGM | |||||||
![]() Connecticut 3-236% -7 -110Caesars | |||||||
#21Notre Dame 2-227% -20½ -110Caesars | |||||||
Nebraska 3-160% -11 -115SugarHouse | |||||||
![]() #5Oklahoma 4-028% -45½ -109BetRivers | |||||||
Arkansas State 1-4100% +14 -115BetRivers | |||||||
![]() Old Dominion 3-129% -20 -113BetRivers | |||||||
Troy 2-222% +1½ -120FanDuel | |||||||
Rice 3-237% -4½ -110Caesars | |||||||
![]() Houston 4-080% +12 -114SugarHouse | |||||||
Wyoming 2-276% +3½ -110Caesars | |||||||
UCF 3-171% +5 -113BetRivers | |||||||
![]() #1Ohio State 4-06% -23½ -110Caesars | |||||||
#18Florida State 3-153% +4½ -110FanDuel | |||||||
TCU 3-130% -13½ -105Caesars | |||||||
#6Texas A&M 4-055% -14½ -115FanDuel | |||||||
![]() Memphis 5-011% -20 -113BetRivers | |||||||
![]() California 4-182% +3 -112BetRivers | |||||||
![]() Fresno State 4-140% -13½ -110Caesars | |||||||
New Mexico State 3-237 +2½ -115SugarHouse |
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