Indiana Hoosiers vs Ohio State Buckeyes Betting Trends

The upcoming Saturday football game on December 6, 2025, features the Indiana Hoosiers vs Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN. This NCAAF regular season Week 15 match is set to be a thrilling contest, broadcast live on FOX. The Hoosiers come in with a strong offensive record, averaging 44.33 points and 254.08 passing yards per game, while the Buckeyes counter with a solid defense limiting opponents to just 203 rushing yards and 121 passing yards on average. Ohio State's starting quarterback, expected to be their top choice, will face a Hoosier defense that allows 172.5 passing yards per game but excels in run defense, only conceding 229.75 rushing yards.

Betting trends favor Ohio State, who are the favorites with a -5.5 point spread and the total points set at 48.5. The Buckeyes boast a perfect 7-0 home record straight up and 6-0 ATS at home, making them a tough opponent on their turf. Indiana, undefeated 5-0 away straight up, holds a 3-2 ATS record on the road, indicating a competitive matchup. Comparing pass offense vs pass defense, Indiana's 254 passing yards per game challenges Ohio State's defense that allows just 121 passing yards. Ohio State's run offense is slightly less potent than Indiana's but benefits from a stronger pass protection and pass rush, which will pressure Indiana's quarterback.

Recent performances reveal Indiana's offensive dominance with a 56-3 win over Purdue and a 31-7 victory against Wisconsin, while Ohio State has been solid with a 42-9 win over Rutgers and a 48-10 win against UCLA. These game stats and betting insights provide bettors valuable information to make informed decisions. The best odds for Ohio State stand at -225 at Caesars, while Indiana offers +182 odds. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

In their last matchup on November 23, 2024, where Ohio State won 38-15, Ohio State Buckeyes dominated Indiana Hoosiers with a strong 38-15 victory. This history adds context to the upcoming game and betting trends to consider. The venue, Lucas Oil Stadium in Indianapolis, IN, will provide a vibrant atmosphere for this high-stakes Week 15 game in the 2025-26 NCAAF season.