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Nov 22, 2025 7:45 PM EST
Week 13
LSU
-21½ (-110)o51 (-110)
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Western Kentucky Hilltoppers vs LSU Tigers Picks
Updated:Nov 22, 2025 1:59 AM EST
The upcoming Saturday football game on November 22, 2025, between the Western Kentucky Hilltoppers and LSU Tigers at Tiger Stadium in Baton Rouge, LA, is set to be an exciting NCAAF matchup. This game will be broadcast on SEC Network and ESPN Networks, making it accessible for fans and bettors alike. Our picks for this game lean heavily towards the LSU Tigers, who are predicted to win with a score of 35-16, covering the spread of LSU -21.5. This prediction is backed by a strong 90.7% hit rate on LSU in the 2-way market and a positive expected value, indicating a smart betting opportunity.
The Western Kentucky Hilltoppers have a respectable history but face a tough challenge against LSU, who have shown profitability in point spread bets in recent games. Our betting tips suggest focusing on the LSU moneyline or spread, as our model has been profitable over the last 10 games, winning 6 out of 10 bets in similar markets with a high EV and hit rate. This insight can help bettors make informed decisions and potentially increase their chances of winning.
For more expert analysis and picks, check out our detailed NCAAF picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
WKUSpread
CONSENSUS LINE
+21½ (-113)
PROJECTION
WKU (16) - LSU (35)
COVER PROBABILITY
EXPECTED VALUE
+4.0%
BET RATING
SEASON COVER %
8/10
80%
EXCLUSIVE BOOSTS
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NCAAF Week 13
NCAAF Sat 11/22
 #1Ohio State 10-031% -31 -115BetRivers | |||||||
 Army 5-423% -9½ -115BetRivers | |||||||
 Wake Forest 7-333% -17½ -110Caesars | |||||||
 Virginia Tech 3-725% +18 -109Caesars | |||||||
 #8Oklahoma 8-235% -5½ -110Bet365 | |||||||
 SMU 7-354% -3½ -117SugarHouse | |||||||
 Iowa State 6-434% -3½ -105BetMGM | |||||||
 Northwestern 5-540% -3½ -110BetMGM | |||||||
 #3Texas A&M 10-0- -54½ -110Bet365 | |||||||
 #4Georgia 9-163% -43½ -112Caesars | |||||||
 Georgia Southern 5-556% +11 -115SugarHouse | |||||||
 James Madison 9-149% -13½ -120FanDuel | |||||||
 Arizona 7-331% -6½ -114Caesars | |||||||
 Toledo 6-469% -27½ -110Bet365 | |||||||
 Wyoming 4-626% -6½ -112Caesars | |||||||
 Kennesaw State 7-321% -6½ -105FanDuel | |||||||
 Auburn 4-6- -27½ -110Bet365 | |||||||
 #10Alabama 8-2- -50½ -107Caesars | |||||||
 Appalachian State 4-673% +5½ -115Caesars | |||||||
 Florida Atlantic 4-684% +7½ -120FanDuel | |||||||
 UTEP 2-824% -3 -113Caesars | |||||||
 Middle Tennessee 1-950% -6½ -113BetRivers | |||||||
 Louisiana Tech 5-524% +1½ -115FanDuel | |||||||
 UAB 3-773% +21½ -109Caesars | |||||||
 North Carolina 4-671% +7 -115BetMGM | |||||||
 #17Texas 7-313% -8 -115BetRivers | |||||||
 #7Oregon 9-160% -10 -110Bet365 | |||||||
 Iowa 6-459% -16½ -110Bet365 | |||||||
 UTSA 5-567% +2½ -108Caesars | |||||||
 #14Vanderbilt 8-217% -8 -115SugarHouse | |||||||
 South Alabama 3-757% +1½ -115BetMGM | |||||||
 Florida International 5-560% -1 -115Bet365 | |||||||
 #9Notre Dame 8-272% -35 -110Bet365 | |||||||
 Temple 5-584% +9½ -105FanDuel | |||||||
 UCF 4-623% -13 -110Bet365 | |||||||
 Maryland 4-672% +14 -107Caesars | |||||||
 #23Houston 8-228% -1 -113BetRivers | |||||||
 #12Utah 8-269% -15½ -125BetMGM | |||||||
 Troy 6-423% -9½ -118FanDuel | |||||||
 South Carolina 3-759% -23½ -122FanDuel | |||||||
 Clemson 5-5- -41½ -110Caesars | |||||||
 Texas State 4-629% -19½ -110Bet365 | |||||||
 #16Georgia Tech 9-117% -2½ -110Bet365 | |||||||
 Penn State 4-634% -7½ -113BetRivers | |||||||
 Boise State 6-40% -16½ -110Bet365 | |||||||
 Air Force 3-789% +4 -120SugarHouse | |||||||
 Florida 3-788% +4½ -112BetRivers | |||||||
 Stanford 3-781% +3½ -113Caesars | |||||||
 Wisconsin 3-757% +8½ -110BetMGM | |||||||
 Rice 5-588% +18½ -115FanDuel | |||||||
 LSU 6-48% -21½ -110Bet365 | |||||||
 Cincinnati 7-338% +3 -113Caesars | |||||||
 Colorado 3-785% +7½ -115Bet365 | |||||||
 UCLA 3-787% +10½ -110Bet365 | |||||||
 San Diego State 8-211% -11½ -114FanDuel | |||||||
 Fresno State 7-317% -2½ -115Bet365 | |||||||
 Ohio 7-442 -33½ -115BetRivers | |||||||
 Bowling Green 3-816 -2½ -110Bet365 | |||||||
 Northern Illinois 3-819 +7½ -122FanDuel | |||||||
 Buffalo 5-620 +2½ -107Caesars | |||||||
 Kent State 4-716 +8½ -115FanDuel | |||||||
 Arkansas State 5-630 -2½ -110Bet365 | |||||||
 North Carolina State 6-521 +7 -118SugarHouse | |||||||
 UNLV 9-238 -2 -121SugarHouse |
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