Nov 22, 2025 3:30 PM EST

Week 13

Syracuse

8-2

#9 Notre Dame

-36½ (-115)o50½ (-110)

NBC

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Syracuse Orange vs Notre Dame Fighting Irish Picks

Updated:Nov 22, 2025 1:39 AM EST

Get ready for an exciting Saturday football showdown on November 22, 2025, as the Syracuse Orange take on the Notre Dame Fighting Irish at the iconic Notre Dame Stadium in South Bend, IN. This NCAAF Week 13 regular-season game promises high stakes and thrilling action broadcasted live on NBC, making it a can't-miss event for college football fans and sports bettors alike.

The matchup between Syracuse and Notre Dame offers intriguing betting opportunities. Our picks favor Syracuse with a predicted score of 43 to 10 against Notre Dame, backing Syracuse at +6.5 on the point spread. This prediction aligns with our recent profitable betting trends, where our point spread picks have hit a 59.3% cover rate with a solid 6.5% expected value, indicating strong betting tips for this contest.

Notre Dame, known for its tough home-field advantage, will be challenged by Syracuse's resilient squad. The Orange's recent performances have shown promise, and bettors should consider this when placing their bets. Our prediction model has been consistently profitable over the last 10 games, especially in point spread markets, helping you make smart betting decisions.

For more insights and expert analysis, check out our detailed NCAAF picks and predictions page where you can explore additional betting tips for the season. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your wager with a U.S. regulated sportsbook to profit off the edge.

What betting markets are recommended for this matchup?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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NCAAF Sat 11/22

Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 69% +31½ -112FanDuel
#1Ohio State 10-0 31% -31 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 77% +10 -105BetMGM
Army 5-4 23% -9½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 67% +18 -120BetRivers
Wake Forest 7-3 33% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 75% -17½ -114FanDuel
Virginia Tech 3-7 25% +18 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 65% +5½ -105BetMGM
#8Oklahoma 8-2 35% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 46% +4 -110Caesars
SMU 7-3 54% -3½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 66% +3½ -113Caesars
Iowa State 6-4 34% -3½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 60% +3½ -105Bet365
Northwestern 5-5 40% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 37% +44 -110Bet365
#4Georgia 9-1 63% -43½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +11 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 51% +14 -110BetMGM
James Madison 9-1 49% -13½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 69% +7 -115Bet365
Arizona 7-3 31% -6½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 31% +28½ -117Caesars
Toledo 6-4 69% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 74% +7½ -120FanDuel
Wyoming 4-6 26% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 79% +6½ -109BetRivers
Kennesaw State 7-3 21% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 27% -4½ -115FanDuel
Appalachian State 4-6 73% +5½ -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 16% -6½ -110Bet365
Florida Atlantic 4-6 84% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 76% +3½ -117BetRivers
UTEP 2-8 24% -3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 50% +6½ -104Caesars
Middle Tennessee 1-9 50% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 76% +2½ -130BetMGM
Louisiana Tech 5-5 24% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 27% -21½ -108FanDuel
UAB 3-7 73% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 29% -6½ -114Caesars
North Carolina 4-6 71% +7 -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 87% +9 -110Bet365
#17Texas 7-3 13% -8 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 40% +10½ -112BetRivers
#7Oregon 9-1 60% -10 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 41% +17½ -120FanDuel
Iowa 6-4 59% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 33% -2 -112SugarHouse
UTSA 5-5 67% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 83% +9½ -110Bet365
#14Vanderbilt 8-2 17% -8 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 43% +1½ -115FanDuel
South Alabama 3-7 57% +1½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 40% +1½ -112FanDuel
Florida International 5-5 60% -1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 28% +36½ -105BetMGM
#9Notre Dame 8-2 72% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 16% -9 -110Bet365
Temple 5-5 84% +9½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +13½ -115Caesars
UCF 4-6 23% -13 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 28% -13½ -120FanDuel
Maryland 4-6 72% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 72% +1½ -110Caesars
#23Houston 8-2 28% -1 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 31% +17½ -112BetRivers
#12Utah 8-2 69% -15½ -125BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 77% +10½ -110Bet365
Troy 6-4 23% -9½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 41% +24 -108Caesars
South Carolina 3-7 59% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +42 -110BetRivers
Clemson 5-5 - -41½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 71% +20½ -110FanDuel
Texas State 4-6 29% -19½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 83% +2½ -105BetMGM
#16Georgia Tech 9-1 17% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 66% +8 -115Bet365
Penn State 4-6 34% -7½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 11% -3½ -102FanDuel
Air Force 3-7 89% +4 -120SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 12% -3½ -118FanDuel
Florida 3-7 88% +4½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 19% -2½ -120FanDuel
Stanford 3-7 81% +3½ -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 43% -8 -114BetRivers
Wisconsin 3-7 57% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 12% -17½ -115BetMGM
Rice 5-5 88% +18½ -112SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 92% +22½ -114FanDuel
LSU 6-4 8% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 62% -2½ -114FanDuel
Cincinnati 7-3 38% +3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 15% -7 -110Caesars
Colorado 3-7 85% +7½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 10% -10½ -105FanDuel
UCLA 3-7 90% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 89% +12½ -110Bet365
San Diego State 8-2 11% -11½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 83% +2½ -104Caesars
Fresno State 7-3 17% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/218:00 PM Florida State 5-6 11 -6½ -114FanDuel
North Carolina State 6-5 21 +7 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/2110:30 PM Hawaii 7-4 10 +2½ -105BetMGM
UNLV 9-2 38 -2 -121SugarHouse

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