Betting Trends for Michigan State Spartans vs Iowa Hawkeyes

The upcoming Saturday football game on November 22, 2025, between the Michigan State Spartans and Iowa Hawkeyes at Kinnick Stadium in Iowa City, IA, is set to be an exciting NCAAF regular season matchup. This game is broadcasted on Fox Sports 1, making it accessible for fans and bettors alike. The Spartans, led by their starting quarterback, face off against the Hawkeyes who have a strong home record and ATS performance, as seen on our NCAAF standings page.

In terms of gameplay, Michigan State's potent passing offense, averaging 212.5 yards per game, will challenge Iowa's solid pass defense that allows only 157.4 yards. Conversely, Iowa's rushing offense, averaging 176.6 yards, faces a tough run defense from Michigan State, allowing just 153.9 yards. Pass protection and pass rush are also key factors, with Michigan State's offensive line providing solid protection against Iowa's aggressive pass rush.

Betting trends show Iowa as the favorite with a -17 point spread and the total points set at 42.5. The Spartans are underdogs but have shown resilience with a 5-5 ATS record. Recent game stats indicate both teams have competitive scoring capabilities, with Iowa scoring 21 points in their last game against USC and Michigan State scoring 28 points against Penn State.

These betting insights can help you make an informed wager. For example, the favorite status of Iowa and the spread suggest a strong chance for Iowa to cover, but Michigan State's solid ATS record as an underdog could provide value. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

In their last matchup on October 19, 2024, Michigan State defeated Iowa 32-20, a game that leaned heavily on Michigan State's strong defense and efficient offense.