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The upcoming NFL clash on December 21, 2025, between the Atlanta Falcons and the Arizona Cardinals at State Farm Stadium in Glendale, AZ, promises an exciting Sunday football matchup. The Falcons enter the game favored with a -3 point spread and odds of -109 at Caesars, while the Cardinals are the underdogs at +3 with +130 odds. The total points line is set at 48, favoring the OVER at -110. This game will be broadcast on FOX, giving fans a great viewing option.
Starting quarterbacks for this game are likely to be Kyle Slovis for the Arizona Cardinals and Michael Penix Jr. for the Atlanta Falcons. Slovis will face a Falcons defense that allows 19.29 points per game, while Penix Jr. will challenge a Cardinals defense that has struggled this season, allowing 27.71 points per game. The Falcons boast a stronger passing offense, averaging 217.7 yards per game, while the Cardinals average 238.4 yards but have a weaker run offense at 95 yards per game compared to Atlanta's 122.7. Both teams have vulnerabilities in pass protection and pass rush that could influence the game's tempo and scoring.
Recent form shows the Cardinals have lost their last seven games, including a 20-40 defeat to the Houston Texans, while the Falcons have a mixed record with some notable wins but also losses, including a recent 29-28 win against Tampa Bay. The Cardinals have a 1-6 home record straight up and 1-6 against the spread at home, while the Falcons are 3-5 away straight up and 5-3 ATS away.
Betting trends suggest caution with the Cardinals struggling at home, but the Falcons' inconsistency means this game could be competitive. The Falcons' slight edge in passing and rushing offense versus the Cardinals' defensive weaknesses could be the key to covering the spread. Fans should watch for the Falcons to exploit turnovers and capitalize on Arizona's penalties.
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In their last matchup on November 12, 2023, the Cardinals narrowly defeated the Falcons 25-23 in a thrilling Sunday football game.
![]() Washington 4-1084% +7 -110Caesars | |||||||
![]() Chicago 10-450% -1 -115SugarHouse | |||||||
Cleveland 3-1155% +10½ -113BetRivers | |||||||
New Orleans 4-1082% -5½ -118FanDuel | |||||||
![]() N.Y. Giants 2-1256% +3 -113Caesars | |||||||
Carolina 7-777% +3 -110Bet365 | |||||||
![]() Tennessee 2-1287% +3 -105BetMGM | |||||||
Dallas 6-7-154% -2 -106Caesars | |||||||
Miami 6-867% +4½ -117SugarHouse | |||||||
Arizona 3-1130% +3 -110Caesars | |||||||
Denver 12-246% -3 -115BetMGM | |||||||
Detroit 8-68% -6½ -120FanDuel | |||||||
![]() Houston 9-533% -14 -110Caesars | |||||||
![]() Baltimore 7-764% -2½ -121SugarHouse | |||||||
![]() Indianapolis 8-683% +6 -110Bet365 | |||||||
Seattle 12-338 -1 -115SugarHouse |
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