Nov 23, 2025 4:05 PM EST

Week 12

Jacksonville

3-7

Arizona

JAX

-2½ (-115)o47½ (-110)

CBS

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Jacksonville Jaguars vs Arizona Cardinals Picks

Updated:Nov 20, 2025 1:16 AM EST

The upcoming NFL showdown on November 23, 2025, features the Jacksonville Jaguars visiting the Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Sunday football game promises excitement and solid betting opportunities for fans and bettors alike. The game will be broadcast on CBS, giving fans nationwide a chance to catch the action live.

Our picks favor the Jacksonville Jaguars with a predicted score of 26 to 20 over the Arizona Cardinals. Jacksonville is predicted to cover the spread at -2.5, boasting a strong 59.7% hit rate and a positive 6.9% EV, making this a smart bet for those looking to capitalize. The total score is expected to go under 47.5 points, supported by a 54.7% hit rate and a 2.3% EV, which shows our American Total market has been profitable recently.

Our model has been profitable in the last 10 games, especially with the Point Spread market for Jacksonville, which has shown a consistent edge. These statistics can help bettors make informed decisions and improve their betting strategies. For more picks and detailed predictions, check out our NFL picks and predictions.

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When is the Jacksonville Jaguars vs Arizona Cardinals game?

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/208:15 PM Buffalo 7-3 28% -5½ -122FanDuel
Houston 5-5 72% +6 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Pittsburgh 6-4 44% +3 -120BetRivers
Chicago 7-3 56% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Jets 2-8 84% +14 -115Bet365
Baltimore 5-5 16% -13½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Giants 2-9 95% +11 -114BetRivers
Detroit 6-4 5% -10½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM New England 9-2 28% -7 -115Caesars
Cincinnati 3-7 72% +7½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Seattle 7-3 16% -12½ -110Bet365
Tennessee 1-9 84% +13½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Minnesota 4-6 83% +6½ -110Caesars
Green Bay 6-3-1 17% -6½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Indianapolis 8-2 73% +3½ -114Caesars
Kansas City 5-5 27% -3½ -102BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Jacksonville 6-4 43% -2½ -112FanDuel
Arizona 3-7 57% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Cleveland 2-8 38% +4 -109BetRivers
Las Vegas 2-8 62% -3½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Atlanta 3-7 33% +1½ -108Caesars
New Orleans 2-8 67% +1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Philadelphia 8-2 46% -3 -113Caesars
Dallas 4-5-1 54% +3½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/238:20 PM Tampa Bay 6-4 64% +6½ -102FanDuel
L.A. Rams 8-2 36% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/248:15 PM Carolina 6-5 91% +7 -109Caesars
San Francisco 7-4 9% -6½ -115Bet365

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