New England Patriots vs Buffalo Bills Betting Trends

The Buffalo Bills are set to clash with the New England Patriots on October 5, 2025, in what promises to be an exhilarating Sunday night football game at Highmark Stadium in Orchard Park, NY. The game will be broadcasted on NBC, giving fans a front-row seat to this thrilling NFL matchup. Buffalo, led by quarterback Josh Allen, boasts a strong offensive line that has been relentless this season. Their pass offense, averaging over 240 yards per game, will challenge New England's secondary. Meanwhile, the Patriots, under the leadership of quarterback Drake Maye, are looking to leverage their solid run defense to counter Buffalo's rushing attack. Buffalo's recent form has been impressive, with a 4-0 straight-up record, showcasing their dominance at home. However, the Patriots have shown resilience on the road, holding a 1-0 away record. With Buffalo favored by 7.5 points and an over/under set at 49.5, bettors should consider the Bills' home advantage and their recent scoring prowess. It's a game that promises high stakes and intense action. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

In their last matchup on January 5th, the Patriots defeated the Bills by a score of 23-16. The Bills will be looking to avenge this defeat and continue their winning streak. The Patriots' ATS record is commendable, and you can explore more on our NFL standings page. With key players like Stefon Diggs and Joey Bosa on the field, this game is set to be a must-watch for all football enthusiasts.