Philadelphia Eagles vs Buffalo Bills Betting Trends

The upcoming NFL showdown on December 28, 2025, between the Philadelphia Eagles and the Buffalo Bills at Highmark Stadium in Orchard Park, NY, promises thrilling Sunday football action. This regular season Week 17 game offers valuable betting trends and game insights for bettors looking to capitalize on the matchup.

Philadelphia Eagles will start their star quarterback Jalen Hurts, who has shown consistent passing prowess with an average of 197.9 passing yards per game this season. Buffalo Bills counter with Josh Allen, whose dynamic playmaking ability has contributed to an impressive 214.2 passing yards per game. The Eagles' defense allows 192.3 passing yards per game, while the Bills allow 167.1, setting the stage for a competitive aerial battle.

Run offense vs run defense is another key factor. The Eagles average 121.7 rushing yards per game, slightly above the Bills' 144.3 rushing yards allowed per game. Buffalo's rushing attack, averaging 158.9 yards per game, faces a tough Eagles run defense allowing just 123.5 yards per game. Pass protection and pass rush will also play crucial roles, with Buffalo's offensive line needing to contain Philadelphia's aggressive pass rush led by Brandon Graham and Jalen Carter.

Buffalo Bills have a 7-8 record against the spread (ATS), while Philadelphia Eagles hold a stronger 9-6 ATS record. The point spread currently favors Buffalo at -1.5 with a total points line of 44.5, suggesting a closely contested game with moderate scoring expectations. Bettors should consider these betting stats and trends when placing wagers.

Injuries could impact the game, with Buffalo's tight end Dawson Knox listed as questionable but likely to play, and Philadelphia's tight end Cameron Latu also questionable. Both teams are expected to field strong lineups, making this a high-stakes encounter.

For bettors seeking a deeper edge, the last matchup on November 26, 2023, saw the Eagles narrowly defeat the Bills 37-34 in a high-scoring affair, which can provide useful context for today's game.

Tune in to FOX on December 28 to catch all the action live. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.