Buffalo Bills vs Philadelphia Eagles Game Props

The upcoming NFL showdown on December 28, 2025, between the Buffalo Bills and Philadelphia Eagles at Highmark Stadium in Orchard Park, NY, is shaping up to be a thrilling Sunday football event. Broadcast on FOX, this Week 17 regular-season game promises plenty of excitement and strategic betting opportunities, especially for game props enthusiasts.

Buffalo Bills boast a strong pass offense that will challenge the Philadelphia Eagles' pass defense, while the Eagles' run offense will test the Bills' run defense. Both teams have solid pass protection and fierce pass rush units, making for an intense battle in the trenches that could influence the pace of play and impact totals and prop bets.

Our prop bets and game projections have shown a high hit rate over the last 10 games, particularly in markets involving touchdowns and field goals. For this matchup, a standout high EV prop bet is the "Player to Score First Touchdown" market, with James Cook III of the Buffalo Bills offering a favorable hit rate and expected value. This prop bet leverages Buffalo's dynamic offense and Cook's role, providing a strategic edge for bettors.

With the game taking place at Highmark Stadium in Orchard Park, NY, weather and outdoor conditions may also play a role in scoring totals and field goal attempts. The Sunday football timing and the teams' contrasting offensive and defensive strengths make this game an ideal candidate for bettors looking to capitalize on team props and totals.

For those looking to enhance their betting strategy, our detailed NFL player props and league picks are invaluable resources. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.