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As the Cleveland Browns gear up to face the Detroit Lions on September 28, 2025, at Ford Field in Detroit, MI, excitement is in the air for this Week 4 NFL showdown. The Lions, with a predicted score of 28, are the favorites against the Browns, who are predicted to score 19. Our predictions favor the Lions to cover the spread with a -8 line. Historically, our picks have been profitable, with a strong hit rate in recent games. Tune in to FOX for all the action and make sure to check out our NFL picks page for more insights. With the Lions' strong home performance and the Browns' struggle on the road, this game promises to be a thrilling encounter. Don't miss the chance to start your OddsTrader Turbo subscription and gain an edge in your betting strategy!
Arizona 2-175% PK -110Caesars | |||||||
![]() Pittsburgh 2-153% +3 -120SugarHouse | |||||||
![]() Tampa Bay 3-070% +3½ -110Caesars | |||||||
Buffalo 3-014% -16 -118BetMGM | |||||||
New England 1-264% -5½ -110Caesars | |||||||
![]() Atlanta 1-275% +2½ -106BetRivers | |||||||
Detroit 2-10% -8 -109BetRivers | |||||||
![]() Houston 0-329% -7 -110Caesars | |||||||
![]() N.Y. Giants 0-386% +6½ -118FanDuel | |||||||
![]() San Francisco 3-021% -3½ +100Caesars | |||||||
![]() L.A. Rams 2-141% -3½ -110Caesars | |||||||
![]() Las Vegas 1-287% PK -110Caesars | |||||||
![]() Kansas City 1-2- +2½ -102FanDuel | |||||||
Dallas 1-278% +7 -115Caesars | |||||||
Miami 0-332% -2½ -118BetMGM | |||||||
Denver 1-215% -7 -110Bet365 |
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