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The Denver Broncos are set to take on the Los Angeles Chargers on September 21, 2025, at SoFi Stadium in Inglewood, CA. This NFL showdown promises an exciting clash of strategies and skills. The Broncos, led by quarterback Bo Nix, will look to bounce back from their recent defeat against the Indianapolis Colts. Meanwhile, the Chargers, with Justin Herbert under center, aim to continue their winning streak following a victory over the Las Vegas Raiders.
Both teams exhibit strong offensive capabilities, but the Chargers have shown a more consistent performance, especially at home. In their last matchup on December 19, 2024, the Chargers secured a 34-27 victory over the Broncos. This time, with a point spread of -3 favoring the Chargers, bettors should consider the Chargers' home advantage and their recent form.
The Broncos' pass offense, led by Nix, will be tested against the Chargers' defensive prowess. However, the Chargers might have the edge with their superior pass rush and Herbert's ability to exploit defensive gaps. With an over/under set at 45.5 points, this game could easily surpass that total given both teams' offensive firepower.
Catch the action live on CBS and place your bets wisely. Check out Caesars for the latest odds and start your OddsTrader Turbo subscription to stay ahead of the game.
![]() Tennessee 0-272% +5 -110Bet365 | |||||||
Carolina 0-273% +5½ -115BetMGM | |||||||
![]() Washington 1-144% -3 +100Caesars | |||||||
Cleveland 0-281% +7½ -110BetRivers | |||||||
Minnesota 1-150% -3 -105BetMGM | |||||||
Philadelphia 2-046% -3½ -104FanDuel | |||||||
New England 1-162% +2 -112BetRivers | |||||||
![]() Tampa Bay 2-021% -6½ -110Caesars | |||||||
Jacksonville 1-161% -1½ -108SugarHouse | |||||||
![]() L.A. Chargers 2-031% -2½ -118BetRivers | |||||||
Seattle 1-118% -7 -113Caesars | |||||||
![]() Chicago 0-284% +1½ -110Caesars | |||||||
![]() San Francisco 2-046% -2 -109BetRivers | |||||||
![]() N.Y. Giants 0-275% +6½ -114BetRivers | |||||||
![]() Baltimore 1-132% -4½ -110Caesars | |||||||
Buffalo 3-031 -11 -110Bet365 |
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