Tennessee Titans vs Houston Texans: Betting Trends

As we gear up for the September 28, 2025, clash between the Tennessee Titans and the Houston Texans at NRG Stadium in Houston, TX, fans and bettors alike are eager to see how this matchup unfolds. The Texans, led by quarterback C.J. Stroud, will look to exploit the Titans' shaky pass defense, which has allowed an average of 228 passing yards per game. Meanwhile, the Titans, with Cam Ward at the helm, aim to capitalize on their solid run game against a Texans defense that has given up 109 rushing yards per game.

The Texans' offensive line will need to fortify their pass protection against the Titans' formidable pass rush, spearheaded by Dre'Mont Jones and Jeffery Simmons. Houston's recent form has seen them struggling, with a 0-3 record in both straight-up and against-the-spread scenarios. Tennessee, on the other hand, has managed a 1-2 record against the spread and will be looking to improve their standing.

With the Texans favored by 7 points and the total points set at 38.5, bettors should consider the Texans' recent head-to-head advantage. In their last matchup on January 5, 2025, the Texans secured a 23-14 victory. For those looking to place a wager, the best odds for the Texans are -7 -109 at Caesars. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook.