Jacksonville Jaguars vs Indianapolis Colts Betting Trends

The upcoming NFL showdown on December 7, 2025, between the Jacksonville Jaguars and the Indianapolis Colts at EverBank Stadium in Jacksonville, FL, is set to be a thrilling Sunday football event broadcasted on CBS. This game offers crucial betting trends and game insights that bettors should not miss.

Jacksonville Jaguars, led by starting quarterback Trevor Lawrence, face the Indianapolis Colts with backup quarterback Daniel Jones stepping in due to Anthony Richardson Sr.'s injury. Lawrence's passing prowess will be tested against a Colts defense that ranks well in limiting passing yards, while the Jaguars' defense will have to contend with the Colts' balanced offensive attack.

Jacksonville's run offense averages 123.25 rushing yards per game, while Indianapolis allows 98.25 rushing yards on defense. Conversely, the Colts' passing offense averages 241 yards per game against a Jaguars defense allowing 230 passing yards. The Colts' pass protection faces a Jaguars pass rush that averages 2 sacks per game, indicating a competitive battle on the line of scrimmage.

The odds favor Indianapolis as a 1.5-point favorite with a total points line at 47.5, suggesting a moderately high-scoring contest. Bettors should consider the Colts' slightly better ATS record of 7-5 and home advantage. Injuries, such as Sauce Gardner's doubtful status for the Colts, could impact defensive effectiveness.

Jacksonville and Indianapolis have a closely contested history, with their last matchup on January 5, 2025, ending in a narrow 26-23 victory for the Colts, a game that went over the projected total points. Bettors can check out the detailed analysis of that game for further insights.

These betting trends and stats provide a valuable edge for bettors aiming to make informed decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.