Miami Dolphins vs Indianapolis Colts Betting Trends

The upcoming clash between the Miami Dolphins and Indianapolis Colts is set to take place on September 7, 2025, at Lucas Oil Stadium in Indianapolis, IN. This NFL season opener promises to be a thrilling encounter as both teams look to set the tone for the season. The Dolphins, led by quarterback Tua Tagovailoa, aim to capitalize on their pass offense against the Colts' defense. Meanwhile, the Colts, with Daniel Jones at the helm, will rely on their home advantage to fend off Miami's aggressive pass rush.

In their last matchup on October 20, 2024, the Colts emerged victorious with a 16-10 win. The game saw Indianapolis cover the spread, with the score falling UNDER 44. The Colts have shown resilience at home, and their recent preseason performance, including a significant win over the Cincinnati Bengals, highlights their potential.

Key players to watch include Miami's Tyreek Hill and Jaylen Waddle, who are crucial in exploiting the Colts' secondary. Indianapolis' Jonathan Taylor will be pivotal in the ground game, challenging Miami's defensive line. The current odds favor the Colts with a -1 spread at Caesars, while the total points are set at 46.5. Bettors should consider the Colts' strong home record and Miami's dynamic offense when placing wagers.

Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.