Colts vs Titans Betting Trends & Insights

Get ready for an electrifying showdown on September 21, 2025, as the Indianapolis Colts face off against the Tennessee Titans in a thrilling NFL Week 3 matchup at Nissan Stadium in Nashville, TN. Both teams are eager to assert their dominance early in the season. Indianapolis, led by quarterback Daniel Jones, has shown a strong offensive front with a total of 445.5 yards per game. Meanwhile, Tennessee, with quarterback Cam Ward, is betting on their defensive prowess, allowing only 378 total yards on average.

In their last encounter, the Colts emerged victorious with a 38-30 score on December 22, 2024. See the full recap here. The Colts are currently favored with a -4 point spread, and the total points are set at 43.5. With the Colts' strong passing offense against the Titans' pass defense, this game promises high stakes for sports bettors.

Key players to watch include Colts' running back Jonathan Taylor, who has been a powerhouse on the ground, and Titans' wide receiver Calvin Ridley, known for his explosive plays. The Colts' pass protection will be tested against the Titans' formidable pass rush led by Jeffery Simmons. With both teams dealing with injuries, particularly in the Titans' offensive line, the dynamics of the game could shift significantly.

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Catch the action live on CBS, and don't miss a moment of this exciting Sunday football clash!