Philadelphia Eagles vs Kansas City Chiefs Picks

The highly anticipated NFL clash between the Philadelphia Eagles and Kansas City Chiefs is set to take place on September 14, 2025, at GEHA Field at Arrowhead Stadium in Kansas City, MO. This game promises to be a thrilling encounter as both teams look to assert their dominance early in the season. The Eagles are coming off a commanding performance, and with a predicted score of 24-20 in favor of Philadelphia, our picks suggest leaning towards the Eagles on the moneyline. The game will be broadcasted on Fox, making it accessible for fans nationwide.

Our prediction model has shown a profitable hit rate in recent games, particularly with the point spread market. The Eagles' spread of -1.5 offers a promising EV of 3.7%, indicating a value bet for those looking to capitalize on this matchup. The total points prediction leans towards the under, with a projected total of 43.93 points, making it another intriguing market to explore.

Historically, the Eagles have had the upper hand in this matchup, and with our predictions favoring them, it’s a prime opportunity for bettors to take advantage of our insights. Our model's accuracy has been consistent, making our picks a reliable source for informed betting decisions. Whether you're placing a wager with a U.S. regulated sportsbook or looking to enhance your strategy with OddsTrader Turbo, this game presents numerous betting opportunities. For more detailed insights, check our NFL picks page.