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The San Francisco 49ers are set to face the Kansas City Chiefs on October 20, 2024, at Levi's Stadium in Santa Clara, CA. This matchup, broadcasted on FOX, is a pivotal game for both teams. The 49ers, led by starting quarterback Brock Purdy, are looking to improve their current season record of 3-4-0. Meanwhile, the Chiefs, with star quarterback Patrick Mahomes, boast an impressive 6-0-0 record. In their last matchup on February 11, 2024, the Chiefs narrowly secured a win with a score of 25-22. The 49ers have struggled against the spread, standing at 3-4-0, whereas the Chiefs are strong at 4-1-1, as seen on our NFL standings page. The current point spread is 2.5 in favor of the 49ers, with a total points line set at 48. Both teams have key injuries, with the 49ers missing Christian McCaffrey and Deebo Samuel being questionable. This game promises to be a thrilling encounter, with the Chiefs' offensive prowess against the 49ers' resilient defense.
PRIORITY
 New Orleans 5-1210 +3 -115BetMGM | |||||||
 Jacksonville 4-1332 -6½ -115Bet365 | |||||||
 Atlanta 8-914 -3 -105BetMGM | |||||||
 Buffalo 15-534 -9 -112FanDuel | |||||||
 Cleveland 3-1414 +5½ -109BetRivers | |||||||
 Green Bay 11-724 -3 -115BetMGM | |||||||
 Indianapolis 8-916 -2½ -120BetRivers | |||||||
 Minnesota 14-429 -1 -115Bet365 | |||||||
 N.Y. Giants 3-143 +3 -104FanDuel | |||||||
 L.A. Rams 11-820 -7 -110Caesars | |||||||
 Washington 14-640 -9½ -120FanDuel | |||||||
 San Francisco 6-1118 -2 -120BetMGM | |||||||
 Pittsburgh 10-837 +3 -121SugarHouse | |||||||
 Tampa Bay 10-831 +4½ -112BetRivers | |||||||
 Arizona 8-917 +1½ -113BetRivers |
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