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The Detroit Lions will face the Arizona Cardinals on September 22, 2024, at State Farm Stadium in Glendale, AZ. The game starts at 4:25 PM EDT and will be broadcast on FOX. In their last matchup on December 19, 2021, the Detroit Lions secured a 30-12 victory over the Arizona Cardinals. Both teams have had a mix of performances this season, with the Lions currently holding a 2-1 record and the Cardinals at 1-2. Jared Goff will be leading the Lions, while Kyler Murray will be the starting quarterback for the Cardinals. Key injuries to watch include Sam LaPorta for the Lions and several defensive players for the Cardinals. The spread for this game is Detroit -3, with a total points line set at 51.5. For more details on their ATS records, visit our NFL standings page.