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The upcoming NFL showdown on November 23, 2025, features the Jacksonville Jaguars visiting the Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Week 12 regular season game is a key matchup for both teams as they battle for playoff positioning. Fans and bettors can catch all the action on CBS, making it a prime opportunity for Sunday football excitement.
Current odds favor the Jacksonville Jaguars as the favorite with a point spread of -2½ -102, compared to the Arizona Cardinals at +2½ -120. The opening odds were quite close, indicating a stable market with little change, suggesting confidence in the Jaguars' ability to leverage their road performance. The over/under is set at 47½ -110, highlighting expectations for a moderately high-scoring game.
Understanding these betting lines is crucial for making a smart wager. Bettors should note the slight edge in odds for the Jaguars, who are expected to cover the spread, while the Cardinals have home-field advantage under a retractable dome, which could influence game dynamics. For those looking to dive deeper, our NFL odds page offers comprehensive insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Seattle - -3½ -110BetOnline | |||||||
![]() L.A. Rams - -3 -120Bovada | |||||||
Jacksonville - -7½ -101Bet105 | |||||||
![]() Cincinnati - -3½ -102Bet105 | |||||||
![]() Indianapolis - +3½ -110BetOnline | |||||||
![]() Pittsburgh - -2½ -122Bet105 | |||||||
![]() Houston - +1½ -120Bovada | |||||||
Carolina - +2½ -102Bet105 | |||||||
![]() Tennessee - -2½ -110Bookmaker | |||||||
Detroit - -7 -105Bet105 | |||||||
![]() L.A. Chargers - -10 -115Bookmaker | |||||||
![]() Las Vegas - -3 -120BetOnline | |||||||
Philadelphia - -4 -103Bet105 | |||||||
Minnesota - +1½ -115Bovada | |||||||
![]() N.Y. Giants - +3 -110MyBookie | |||||||
![]() Kansas City - -2½ -110MyBookie |