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Get ready for an electrifying showdown between the San Francisco 49ers and the Arizona Cardinals at Levi's Stadium in Santa Clara, CA. This game, airing on FOX at 4:05 PM ET on October 6, 2024, promises to be a thrilling contest. The 49ers, led by starting quarterback Brock Purdy, are looking to capitalize on their strong home performance, having won both home games this season. The Cardinals, with Kyler Murray at the helm, are eager to bounce back after a series of tough losses. In their last matchup on December 17, 2023, the 49ers dominated with a 45-29 victory. See the full recap. The 49ers are favored by 7.5 points, and the over/under is set at 49 points. You can check the detailed ATS records on our NFL standings page. With the odds spread favoring San Francisco, bettors should consider the 49ers' home field advantage and recent form. This game is crucial for both teams as they navigate the regular season, and it could be a pivotal moment for bettors looking to make informed decisions.