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In the upcoming NFL showdown featuring the Arizona Cardinals vs San Francisco 49ers, our predictions favor the Arizona Cardinals with a predicted score of 24 against the San Francisco 49ers' 19. Our betting model suggests the Cardinals have a strong 68.8% chance of covering the spread, making them a promising pick for bettors. However, the total predicted score of 42.973 suggests a slight lean towards the under 42.5 market. For more insights and to see how our predictions have performed recently, check out our NFL picks page.