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As the 2024 NFL season heats up, fans eagerly anticipate the upcoming clash between the San Francisco 49ers and the Arizona Cardinals at State Farm Stadium in Glendale, AZ. Scheduled for January 5th at 4:25 PM ET, this game promises high-stakes action as both teams aim to close their regular season on a high note. The Cardinals, who are favored with a point spread of -4.5, have shown a strong home record, evident on our NFL standings page. Arizona's defense will be pivotal, especially with the 49ers missing key players like Deebo Samuel and Brock Purdy. San Francisco, however, will rely on their dynamic offense, led by backup QB Tanner Mordecai, to exploit any weaknesses in the Cardinals' lineup. The last encounter between these teams was a nail-biter, with Arizona narrowly defeating San Francisco 24-23 on October 6th, 2024, as detailed in their last matchup. With odds set at a total of 43 points, bettors are keen to see whether the game will go over or under this mark. Tune in on FOX to catch this thrilling matchup live.