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As the Chicago Bears prepare to face the San Francisco 49ers on December 8, 2024, at Levi's Stadium in Santa Clara, CA, fans can anticipate a thrilling matchup. In their last matchup on September 11, 2022, the Bears emerged victorious with a final score of 19-10. The game will air on FOX at 4:25 PM ET, and bettors are eagerly analyzing the odds. The 49ers are favored with a -3 point spread, while the total points are set at 43.5. Chicago's Caleb Williams steps in as the starting quarterback amid a challenging season, where the Bears hold a 4-8 straight-up record, as seen on our NFL standings page. On the other hand, San Francisco's Brock Purdy leads his team, aiming to improve their 5-7 record. The 49ers' recent losses to the Buffalo Bills and Green Bay Packers have bettors questioning their defensive strategies. With key players like Christian McCaffrey and Javon Hargrave on injured reserve, the 49ers face an uphill battle. Meanwhile, the Bears' D'Andre Swift, though questionable, is expected to play, potentially boosting their offensive lineup. This game is poised to be a strategic showdown, with both teams eager to capitalize on their strengths.