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Get ready for an electrifying Thursday night football as the Seattle Seahawks take on the Arizona Cardinals on September 25, 2025, at State Farm Stadium in Glendale, AZ. This NFC West showdown promises to keep fans on the edge of their seats. With the Seahawks coming in as favorites, sporting a point spread of -1½ -110 at Caesars, bettors are keen to see if they can cover. Meanwhile, the Cardinals are looking to leverage their home advantage with odds at +1½ -110.
The betting lines have seen some movement since the opening, reflecting the intense rivalry and the high stakes involved. The opening odds had the Seahawks at -130 on the Moneyline, indicating a strong confidence in their ability to win straight up. However, the Cardinals, with their underdog status, offer a tempting +110 on the Moneyline for those looking to back an upset.
For those interested in totals, the over/under is set at 43.5, with both sides priced at -110. This suggests a closely contested game with potential fireworks on the field. Catch all the action on Amazon Prime Video and make sure to check out our NFL odds page for the latest updates.
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