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Before the Seattle Seahawks take on the Arizona Cardinals on September 25, 2025, at State Farm Stadium in Glendale, AZ, fans and bettors alike are eagerly anticipating this Thursday night football clash. The NFL matchup, broadcasted on Amazon Prime Video, promises an exciting contest between two competitive teams. Our picks suggest a slight edge for the Arizona Cardinals, with a predicted score of 22-20 in their favor. Despite a challenging start to the season, the Seahawks have shown resilience, but the Cardinals' home advantage could be pivotal. Our prediction model has been quite effective, particularly on point spreads, with a solid hit rate over recent games. Bettors should consider the Cardinals' point spread as a viable option. With our prediction insights and a visit our NFL picks page for more detailed analysis, you can make informed betting decisions. Ready to up your game? Start your OddsTrader Turbo subscription now for more winning insights.