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The Buffalo Bills will host the Jacksonville Jaguars on September 23, 2024, at Highmark Stadium in Orchard Park, NY. The game starts at 7:30 PM ET and will be broadcast live on ESPN. In their last matchup on October 8, 2023, the Jaguars defeated the Bills 25-20. Buffalo, led by quarterback Josh Allen, will look to bounce back after their previous defeat. Jacksonville's quarterback Trevor Lawrence will aim to continue his strong performance. Key players like Buffalo's linebacker Matt Milano and Jacksonville's tight end Evan Engram are out due to injuries. The current odds have Buffalo as 5.5-point favorites with a total points line set at 45.5. Check the NFL standings page for the latest ATS records. With both teams having fluctuating performances, this game is crucial for both sides to establish momentum this season.