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FINAL
Oct 5, 2025 8:20 PM EDT
NE 23 vs BUF 20
Week 5
BUF
-7½ (-105)o48½ (-115)
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New England Patriots vs Buffalo Bills Picks
Updated:Oct 5, 2025 3:01 AM EDT
Before the highly anticipated matchup between the Buffalo Bills and the New England Patriots on October 5, 2025, at Highmark Stadium in Orchard Park, NY, NFL fans are buzzing with excitement. The Bills, led by a strong offense, are predicted to win with a score of 27-19, according to our expert picks. This game, broadcasted on NBC, promises to be a thrilling Sunday night football event. Our prediction model favors the Bills with a 76.1% win probability, making them a solid bet. The point spread for Buffalo is -8, and for New England, it's +8.5. Our model has had a profitable run, accurately predicting 6 out of the last 10 games. For those looking to make smart betting decisions, our picks page offers valuable insights. Check out our NFL picks for more detailed analysis. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
BUFSpread
CONSENSUS LINE
-7½ (-105)
PROJECTION
BUF (27) - NE (20)
COVER PROBABILITY
EXPECTED VALUE
-0.9%
BET RATING
SEASON COVER %
2/4
50%
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