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FINAL
Nov 16, 2025 1:00 PM EST
TB 32 vs BUF 44
Week 11
BUF
-6½ (-115)o45½ (-107)
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Tampa Bay Buccaneers vs Buffalo Bills Picks
Updated:Nov 16, 2025 1:34 AM EST
The upcoming NFL game on November 16, 2025, features the Tampa Bay Buccaneers visiting the Buffalo Bills at Highmark Stadium in Orchard Park, NY. This Sunday football matchup promises to be an exciting contest for fans and bettors alike, broadcasted on CBS. The Buffalo Bills are predicted to win with a score of 25 to 21 against the Buccaneers, covering a spread of -5.5. Our picks are based on a profitable prediction model that has demonstrated a strong hit rate, particularly in 2-way markets where the model has won 62.8% of the time in recent games. Additionally, the under 47 bet shows a positive expected value (EV) and a cover percentage of 52.6%, suggesting a lower-scoring game is likely. These betting tips can help you place smarter wagers and increase your chances of winning. For more detailed NFL insights and expert predictions, check out our NFL picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
TBSpread
CONSENSUS LINE
+6 (-107)
PROJECTION
BUF (25) - TB (21)
COVER PROBABILITY
EXPECTED VALUE
+1.1%
BET RATING
SEASON COVER %
5/9
56%
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