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Get ready for a thrilling NFL showdown as the Houston Texans take on the Jacksonville Jaguars at EverBank Stadium in Jacksonville, FL. Scheduled for September 21, 2025, this Sunday football clash promises to be an exhilarating encounter. Broadcasted on CBS, the game will see the Texans seeking redemption after their narrow 20-19 loss to the Tampa Bay Buccaneers on September 15. Houston's quarterback, C.J. Stroud, will aim to exploit Jacksonville's pass defense, which has allowed an average of 222 passing yards per game. Meanwhile, Jacksonville's Trevor Lawrence will look to capitalize on Houston's defensive vulnerabilities, having recorded an impressive 219.5 passing yards on average. With point spread odds favoring the Jaguars by -1.5 and a total points line set at 43.5, bettors should consider the Texans' recent underdog performance against the Buccaneers. Both teams have faced off multiple times, with their last matchup on December 1, 2024, ending in a 23-20 victory for the Texans. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.