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Gear up for a thrilling Monday night football showdown as the Kansas City Chiefs take on the Jacksonville Jaguars on October 6, 2025. This NFL clash at EverBank Stadium in Jacksonville, FL, promises to be an electrifying matchup. The Chiefs, led by their dynamic offense, are the favorites with a point spread of -3½ -110 according to Caesars. Meanwhile, the Jaguars are looking to capitalize on their home advantage and upset the odds at +3½ -110. With betting odds shifting from the opening lines, it's crucial for bettors to stay updated. The over/under is set at 45.5, providing intriguing opportunities for those looking at totals. Catch all the action live on ABC/ESPN and make informed bets with insights from our NFL odds page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.