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Sep 28, 2025 4:05 PM EDT
JAX 26 vs SF 21
Week 4
SF
-3 (-110)o46 (-114)
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Jacksonville Jaguars Vs San Francisco 49ers Odds
Updated:Sep 28, 2025 3:58 AM EDT
Get ready for an exciting NFL showdown as the Jacksonville Jaguars take on the San Francisco 49ers at Levi's Stadium in Santa Clara, CA, on September 28, 2025. As the 49ers host the Jaguars, fans are in for a thrilling Sunday football matchup. Both teams are eager to make a statement in Week 4 of the 2025-26 NFL season, and bettors are keen to find the best odds and betting lines.
The Jaguars enter as underdogs with a Point Spread of +3½ -120, while the 49ers are favored at -3½ +100, according to Caesars. This game offers a great opportunity for bettors looking to capitalize on the betting odds. The moneyline sees the Jaguars at +150 and the 49ers at -190, reflecting the tight competition expected between these two teams.
For those interested in the American Total market, the over is set at o46½ -110, while the under is at u46½ -112. These odds provide an opportunity for strategic betting, especially as both teams have shown the capability to score heavily in past encounters.
Join the action on NFL odds page to explore more betting options and make informed decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
JacksonvilleSpread
+0.3%
EV
+0.3%
San FranciscoSpread
-5.4%
EV
-5.4%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
JacksonvilleMONEYLINE
+7.2%
EV
+7.2%
San FranciscoMONEYLINE
-9.4%
EV
-9.4%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-7.1%
EV
-7.1%
UNDERTotal
-3.9%
EV
-3.9%
Spread (1H)
BEST LINE
JacksonvilleSpread
San FranciscoSpread
MONEYLINE (1H)
BEST LINE
JacksonvilleMONEYLINE
San FranciscoMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
JacksonvilleSpread
San FranciscoSpread
MONEYLINE (2H)
BEST LINE
JacksonvilleMONEYLINE
San FranciscoMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
JacksonvilleSpread
San FranciscoSpread
MONEYLINE (1Q)
BEST LINE
JacksonvilleMONEYLINE
San FranciscoMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
JacksonvilleSpread
San FranciscoSpread
MONEYLINE (2Q)
BEST LINE
JacksonvilleMONEYLINE
San FranciscoMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
JacksonvilleSpread
San FranciscoSpread
MONEYLINE (3Q)
BEST LINE
JacksonvilleMONEYLINE
San FranciscoMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
JacksonvilleSpread
San FranciscoSpread
MONEYLINE (4Q)
BEST LINE
JacksonvilleMONEYLINE
San FranciscoMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
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