Week 15 in the 2025 college football season means big conference championship games this Friday and Saturday. We are looking at the live college football odds for what could be some of the best games of the season before we get to the actual playoffs.
For the college football odds Week 15, we’ll preview the biggest matchups with the early lines from top-rated sportsbooks.
NCAAF Odds Week 15 At-a-Glance
For this week’s college football odds, we are hyping up the two most marquee games this Saturday. First, it’s the SEC Championship Game in a familiar matchup with No. 4 Georgia vs. No. 10 Alabama. Then in the evening, it’s the Big Ten Championship between No. 1 Ohio State and No. 2 Indiana, who are both 12-0.
Georgia Bulldogs vs. Alabama Crimson Tide (+2.5)
Saturday, December 6, 2025 – 04:00 PM ET
The big SEC matchup we’re used to seeing will decide the conference champion as the Georgia Bulldogs (11-1) and Alabama Crimson Tide (10-2) meet again. Alabama is the only team to defeat Georgia this year in what was a 24-21 final in Week 4. Alabama led that game wire-to-wire with a strong 14-0 start, then held onto that 24-21 advantage for the final quarter and a half.
Alabama held Georgia quarterback Gunner Stockton to 130 passing yards, his fewest of the season until he had 70 yards against Georgia Tech last week. But the Bulldogs were able to run for 227 yards against the Crimson Tide, something only Florida State (230) was able to do in the season opener.
Georgia coach Kirby Smart is just 1-7 against Alabama, his only win coming in the national championship game in January 2022. He is 0-2 against new coach Kalen DeBoer these last two seasons, including a 41-34 loss last season. So, Alabama has certainly been Kirby’s kryptonite.Â
Georgia opened as a 1.5-point favorite, and the line has moved up to 2.5 at some sportsbooks. Georgia is just 5-7 ATS this season, while Alabama is 8-3-1 ATS. The total is 47.5 points, but this could be a game for the under with the way Georgia’s offense played last week in a 16-9 win over Georgia Tech. Meanwhile, the over is just 2-6 in SEC games for the Crimson Tide this year.
Alabama and quarterback Ty Simpson survived the Iron Bowl against Auburn last week in a 27-20 win. Another tight battle with its SEC rival from Georgia in Atlanta is exactly what we’d expect from the SEC Championship Game this year.
Indiana Hoosiers vs. Ohio State Buckeyes (-5.5)
Saturday, December 6, 2025 – 08:00 PM ET
It’s the Big Ten matchup we’ve been waiting to see for weeks as the No. 1 and No. 2 teams from Ohio State and Indiana will put their 12-0 records on the line for superiority in the Big Ten and the momentum as the No. 1 seed in the 2025-26 College Football Playoffs.
It’s a pretty great matchup on paper as you have Heisman Trophy candidate quarterback Fernando Mendoza leading Indiana’s No. 2 scoring offense against Ohio State’s No. 1 scoring defense that only allows 7.8 points per game. However, Indiana is no slouch as it ranks No. 2 in scoring defense at 10.9 points per game.Â
Ohio State’s offense is also very formidable, with young quarterback Julian Sayin completing 78.9% of his passes to a great cast and behind a strong offensive line. His numbers are right on par with Mendoza’s, but his team is considered so much more talented that he isn’t the Heisman favorite over him. That could be a chip on his shoulder, and don’t look past running back Bo Jackson, who had 952 yards for the Buckeyes this year.
But while Indiana is a nation-best +33.4 in scoring differential, they were only 7-5 ATS and pushed in close games against Iowa (20-15), Oregon (30-20), and Penn State (27-24). Meanwhile, after beating Texas by a 14-7 final in Week 1, Ohio State (10-1-1 ATS) has won every game by at least 18 points.
Ohio State opened as a 5.5-point favorite, and that’s where the line is staying so far. The total has slightly dropped from 49.5 to 48.5 points. Ohio State beat a solid Indiana team last year by a 38-15 score, but we’ll see if Mendoza leading a superior offense can keep up and penetrate that outstanding defense.Â
Bet on College Football Now!
We’ve covered the NCAAF odds Week 15 for the best matchups in conference championship games this week with small spreads.
Our most anticipated game is between No. 1 Ohio State and No. 2 Indiana to determine the No. 1 seed in the playoffs and who stays undefeated. But you also can’t go wrong with betting on a classic SEC rivalry between Georgia and Alabama either.Â
Timing is always important in sports betting. If you register with top-rated sportsbooks, you will find competitive odds for games like the ones above, or other college football game picks this week.
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*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.
