Detroit Tigers vs Cleveland Guardians Picks

As the Detroit Tigers prepare to face off against the Cleveland Guardians on September 30, 2025, at Progressive Field in Cleveland, OH, anticipation is mounting among MLB fans and bettors alike. The Tigers, with a strong record against right-handed pitchers, are poised to challenge the Guardians who have demonstrated resilience in their recent performances. This game, airing on ESPN, promises to be a thrilling start to the series. Our prediction model gives Detroit a slight edge with a predicted score of 4-3, favoring the Tigers to win on the moneyline. The spread suggests a closer battle, with a 58.3% probability for Cleveland to cover +1.5. Bettors should also consider the total score prediction, leaning towards over 6 with a 53.2% probability. Our past predictions have shown profitability, winning 6 out of the last 10 games. For more insights and detailed MLB picks, visit our MLB picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.