Philadelphia 76ers vs Boston Celtics Betting Trends

The upcoming NBA regular season game on October 22, 2025, between the Philadelphia 76ers and the Boston Celtics at TD Garden in Boston, MA, promises an intense basketball showdown. This matchup is a must-watch for fans and bettors alike, airing on NBCS-BOS and NBCS-PH. The Celtics enter as favorites with a -2.5 point spread and odds of -115, while the 76ers are the underdogs with +2.5 and odds at -105. The total points over/under is set at 225.5, indicating a potentially high-scoring game.

Both teams have shown strong offensive and defensive performances in recent games. The Celtics have a recent win against Toronto by 110-108, while the 76ers secured a 126-110 victory over Minnesota. Boston's points per game and defensive stats suggest a balanced team capable of controlling the pace, while Philadelphia's scoring power and defense make them a formidable opponent. Key players from both teams are expected to start, with any questionable injuries likely not affecting their participation.

In their last matchup on March 6, 2025, the Celtics dominated the 76ers 123-105, covering a -13.5 spread. This historical context, combined with current season stats and betting trends, offers valuable betting insights. Bettors should consider the point spread and total points to make informed wagers. The Celtics' home advantage at TD Garden also plays a crucial role in the betting outlook.

For fans looking to bet smart, this game provides ample opportunity. The best lines for Boston are -2.5 -115 at Caesars, while Philadelphia sits at +2.5 -105. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Check out the detailed betting trends and stats to maximize your chances of winning in this thrilling NBA encounter.