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The upcoming Saturday football game on November 22, 2025, features the Missouri Tigers visiting the Oklahoma Sooners at the Gaylord Family Oklahoma Memorial Stadium in Norman, OK. This NCAAF regular season Week 13 matchup promises exciting betting trends and game insights for bettors looking to capitalize on the action. Oklahoma, hosting the game, has a solid 8-2 straight-up record and a 6-4 ATS record, while Missouri holds a respectable 7-3 straight-up and 6-4 ATS record, making this a tight contest with plenty of wagering intrigue.
Starting quarterbacks will play a crucial role in this game. Oklahoma’s QB leads a passing offense averaging 226.8 yards per game with a solid 60.5 points per game, while Missouri’s QB commands a higher rushing yard average at 241.7 yards per game and 52.9 points per game. Defensively, Oklahoma’s team allows just 196.2 passing yards and 82.2 rushing yards per game, while Missouri's defense is slightly more permissive, allowing 169.9 passing yards and 107.6 rushing yards. This contrast sets up an intriguing battle of pass offense versus pass defense and run offense against run defense.
The Sooners’ pass protection is tested against Missouri’s pass rush, with Oklahoma allowing 13.8 sacks yards while Missouri's defense sacks and pressures quarterbacks less frequently. The betting odds favor Oklahoma with a -6.5 point spread and a total points over/under of 42, indicating a moderately high scoring game. The best odds for Oklahoma are -113 at Caesars, while Missouri is +6.5 at -107, providing a nice edge for bettors.
Missouri enters this game coming off a 27-49 win over Mississippi State, showing strong offensive output, while Oklahoma recently secured a narrow 23-21 victory against Alabama. These recent performances and their impact on the teams’ momentum are key betting insights to consider.
Fans can watch the game on ABC and ESPN networks, making it accessible for viewers nationwide. For those wanting to dive deeper into the betting trends and stats, Start your OddsTrader Turbo subscription for expert analysis and Caesars for the best sportsbook odds. Also, check out their last matchup on November 9, 2024, where Missouri won 30-23 for context on how these teams match up.
![]() North Carolina State 5-544% +6 -108Caesars | |||||||
UNLV 8-241% -2 -129SugarHouse | |||||||
![]() #1Ohio State 10-030% -31½ -110FanDuel | |||||||
Army 5-436% -9½ -120FanDuel | |||||||
![]() Wake Forest 7-330% -17½ -110Caesars | |||||||
Virginia Tech 3-762% +18½ -113BetRivers | |||||||
![]() #8Oklahoma 8-234% -6½ -110Bet365 | |||||||
SMU 7-324% -2½ -110Bet365 | |||||||
![]() Iowa State 6-435% -3½ -108Caesars | |||||||
![]() Northwestern 5-539% -3½ -110BetMGM | |||||||
#3Texas A&M 10-0- -54½ -110Bet365 | |||||||
![]() #4Georgia 9-148% -43½ -110Bet365 | |||||||
![]() Georgia Southern 5-556% +12½ -115BetMGM | |||||||
![]() James Madison 9-131% -13½ -110Bet365 | |||||||
![]() Arizona 7-330% -6½ -120FanDuel | |||||||
![]() Toledo 6-487% -27½ -110Bet365 | |||||||
Wyoming 4-610% -6½ -112Caesars | |||||||
![]() Kennesaw State 7-322% -6½ -105FanDuel | |||||||
Auburn 4-6- -27½ -110Bet365 | |||||||
#10Alabama 8-2- -50½ -110FanDuel | |||||||
Appalachian State 4-664% +5½ -114Caesars | |||||||
![]() Florida Atlantic 4-688% +7½ -120FanDuel | |||||||
![]() UTEP 2-825% -3 -110Bet365 | |||||||
![]() Middle Tennessee 1-940% -6½ -113BetRivers | |||||||
![]() Louisiana Tech 5-530% +1½ -117SugarHouse | |||||||
UAB 3-772% +21½ -109Caesars | |||||||
![]() North Carolina 4-682% +7 -113Caesars | |||||||
![]() #17Texas 7-315% -8½ -110FanDuel | |||||||
![]() #7Oregon 9-146% -9½ -118SugarHouse | |||||||
Iowa 6-429% -16½ -110Bet365 | |||||||
![]() UTSA 5-581% +2½ -108Caesars | |||||||
![]() #14Vanderbilt 8-211% -8½ -110Caesars | |||||||
![]() South Alabama 3-754% +2½ -110FanDuel | |||||||
![]() Florida International 5-586% +1½ -120Caesars | |||||||
#9Notre Dame 8-267% -35 -110Bet365 | |||||||
Temple 5-578% +9½ -112Caesars | |||||||
UCF 4-623% -13 -110Caesars | |||||||
Maryland 4-673% +14 -107Caesars | |||||||
![]() #23Houston 8-243% -1 -114BetRivers | |||||||
![]() #12Utah 8-226% -17 -110Bet365 | |||||||
Troy 6-443% -10 -110BetMGM | |||||||
![]() South Carolina 3-730% -23½ -122FanDuel | |||||||
![]() Clemson 5-5- -41½ -110FanDuel | |||||||
Texas State 4-667% -18 -113BetRivers | |||||||
![]() #16Georgia Tech 9-18% -2½ -110Bet365 | |||||||
![]() Penn State 4-637% -8 -112Caesars | |||||||
![]() Boise State 6-40% -16½ -110Bet365 | |||||||
Air Force 3-792% +4 -118SugarHouse | |||||||
Florida 3-781% +4½ -115BetMGM | |||||||
Stanford 3-783% +3½ -114Caesars | |||||||
![]() Wisconsin 3-788% +8½ -110BetMGM | |||||||
Rice 5-580% +18½ -114BetRivers | |||||||
LSU 6-431% -21½ -110Bet365 | |||||||
![]() Cincinnati 7-386% +2½ -105Caesars | |||||||
![]() Colorado 3-787% +7½ -114FanDuel | |||||||
UCLA 3-785% +10½ -110Bet365 | |||||||
San Diego State 8-212% -12 -115SugarHouse | |||||||
![]() Fresno State 7-30% -2½ -115Bet365 | |||||||
![]() Ohio 7-442 -33½ -115BetRivers | |||||||
Bowling Green 3-816 -2½ -110Bet365 | |||||||
![]() Northern Illinois 3-819 +7½ -122FanDuel | |||||||
Buffalo 5-620 +2½ -107Caesars | |||||||
![]() Kent State 4-716 +8½ -115FanDuel | |||||||
Arkansas State 5-630 -2½ -110Bet365 |
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