Nov 22, 2025 3:30 PM EST

Week 13

3-7

Syracuse

8-2

#9 Notre Dame

-35½ (-110)o50½ (-110)

NBC

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Syracuse Orange vs Notre Dame Fighting Irish Betting Trends

Updated:Nov 21, 2025 1:26 AM EST

The upcoming Saturday football game on November 22, 2025, between the Syracuse Orange and Notre Dame Fighting Irish at Notre Dame Stadium in South Bend, IN, promises an exciting showdown in the 2025-26 NCAAF season. Notre Dame, favored by 36 points with a total set at 50.5, boasts a strong offensive record, averaging 458.2 total yards per game with a balanced attack of 265.7 passing yards and 192.5 rushing yards. Their defense effectively limits opponents to 323.3 total yards and 62.7 rushing yards per game. Syracuse, on the other hand, has struggled this season with a 3-7 record but can surprise with a dynamic passing game averaging 244.7 yards per game. The starting quarterbacks for both teams are expected to play, with Notre Dame’s offense showing a slight advantage in pass protection against Syracuse’s pass rush, which could be a decisive factor in the game.

Notre Dame’s home record is solid at 5-1, and their ability to cover the spread stands at 3-3 at home, while Syracuse holds a 3-2 away ATS record. This game will be broadcast on NBC, offering fans and bettors alike a chance to catch the action live. The previous meeting on October 29, 2022, saw Notre Dame defeat Syracuse 41-24, a game that went over the total points line of 48.

Key betting insights include Notre Dame’s strong performance against the spread when favored heavily and the total points line suggesting a moderately high-scoring game. Bettors should consider Notre Dame’s superior run offense against Syracuse’s run defense, which could control the pace and scoring opportunities. The best odds available today for Syracuse is +36 at Caesars and for Notre Dame -36 at Caesars. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What are the latest betting trends for Syracuse Orange vs Notre Dame Fighting Irish?

ATS Records

Syracuse

Notre Dame

All

All
1st half
2nd half
1st quarter
2nd quarter
3rd quarter
4th quarter

4-5-1 (184th)Against the Spread5-5 (123rd)

3-7 (211th)Straight Up8-2 (34th)

-0.6Straight Up Units-0.9

5-5Over / Under5-5

TEAM MATCHUP

Syracuse

Notre Dame

OFF

DEF

OFF

DEF

22.3Points38.5

361.9Total Yards458.2

5.1Yards Per Play7.5

244.7Passing Yards265.7

20.4 - 36.1 (56.5%)Completions-Attempts18.5 - 27.2 (68%)

6.8Yards Per Passing Play9.8

22.8Sacks-Yards Lost9.1

117.2Rushing Yards192.5

34.6Attempts36.7

3.4Yards Per Rush5.2

20.31st Downs23.1

10.7Passing11.8

8Rushing9.1

1.6Penalties2.2

4.9 / 14.1 (34.8%)3rd Down5 / 11 (45.5%)

1.3 / 2.7 (48.1%)4th Down1.3 / 2.7 (48.1%)

2.8 / 3.6 (77.8%)Red Zone3.5 / 4.7 (74.5%)

6.1 (54.2)Penalties (Yards)5.8 (54.7)

1.2Interceptions0.6

0.8Fumbles Lost0.4

73.8Total Plays65

4.4Kickoffs6.7

2Returns1.6

40Yards49.2

20Yards Per Return30.8

5Punts2

1Returns1.5

5.8Yards16.2

5.8Yards Per Return10.8

HEAD TO HEAD

Syracuse

SYR

Notre Dame

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

NCAAF Fri 11/21

Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/218:00 PM Florida State 5-5 56% -5½ -110BetMGM
North Carolina State 5-5 44% +6 -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/2110:30 PM Hawaii 7-3 59% +3 -110Bet365
UNLV 8-2 41% -2 -129SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 70% +32½ -110BetRivers
#1Ohio State 10-0 30% -31½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 64% +10 -105BetMGM
Army 5-4 36% -9½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 70% +17½ -108FanDuel
Wake Forest 7-3 30% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 38% -17½ -110Bet365
Virginia Tech 3-7 62% +18½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 66% +7 -110BetMGM
#8Oklahoma 8-2 34% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 76% +3 -113Caesars
SMU 7-3 24% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 65% +3½ -105BetMGM
Iowa State 6-4 35% -3½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 61% +4 -118BetRivers
Northwestern 5-5 39% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 52% +44 -114BetRivers
#4Georgia 9-1 48% -43½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +12½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 69% +14 -113BetRivers
James Madison 9-1 31% -13½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 70% +7 -114Caesars
Arizona 7-3 30% -6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 13% +28½ -122FanDuel
Toledo 6-4 87% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 90% +7½ -120FanDuel
Wyoming 4-6 10% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 78% +6½ -110BetMGM
Kennesaw State 7-3 22% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 36% -4½ -114BetRivers
Appalachian State 4-6 64% +5½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 12% -7 -110Caesars
Florida Atlantic 4-6 88% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 75% +3½ -117BetRivers
UTEP 2-8 25% -3 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 60% +6½ -104Caesars
Middle Tennessee 1-9 40% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 70% +1½ -125BetMGM
Louisiana Tech 5-5 30% +1½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 28% -21½ -108FanDuel
UAB 3-7 72% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 18% -6½ -120FanDuel
North Carolina 4-6 82% +7 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 85% +9 -110Bet365
#17Texas 7-3 15% -8½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 54% +10 -110Bet365
#7Oregon 9-1 46% -9½ -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 71% +17 -110Caesars
Iowa 6-4 29% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 19% -2½ -110Bet365
UTSA 5-5 81% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 89% +9½ -110Bet365
#14Vanderbilt 8-2 11% -8½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 46% -1½ -107Caesars
South Alabama 3-7 54% +2½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 14% +½ -110SugarHouse
Florida International 5-5 86% +1½ -120Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 33% +36 -110Caesars
#9Notre Dame 8-2 67% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 22% -7½ -115FanDuel
Temple 5-5 78% +9½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +14 -110Bet365
UCF 4-6 23% -13 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 27% -13½ -120FanDuel
Maryland 4-6 73% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 57% +2 -110Bet365
#23Houston 8-2 43% -1 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 74% +17½ -110BetMGM
#12Utah 8-2 26% -17 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 57% +10½ -110Bet365
Troy 6-4 43% -10 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 70% +24 -108Caesars
South Carolina 3-7 30% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +41½ -110FanDuel
Clemson 5-5 - -41½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 33% +19½ -110Bet365
Texas State 4-6 67% -18 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 92% +3 -117BetRivers
#16Georgia Tech 9-1 8% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 63% +9½ -104FanDuel
Penn State 4-6 37% -8 -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 8% -3½ -102FanDuel
Air Force 3-7 92% +4 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 19% -3½ -118FanDuel
Florida 3-7 81% +4½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 17% -2½ -120FanDuel
Stanford 3-7 83% +3½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 12% -8 -114BetRivers
Wisconsin 3-7 88% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 20% -17½ -115BetMGM
Rice 5-5 80% +18½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 69% +22 -112Caesars
LSU 6-4 31% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 14% -2 -110Bet365
Cincinnati 7-3 86% +2½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 13% -7 -110Caesars
Colorado 3-7 87% +7½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 15% -10½ -109Caesars
UCLA 3-7 85% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 88% +12½ -110BetMGM
San Diego State 8-2 12% -12 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 100% +3 -113BetRivers
Fresno State 7-3 0% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365

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Syracuse Orange vs Notre Dame Fighting Irish Betting Trends

ATS Records

Syracuse

Notre Dame

TEAM MATCHUP

Syracuse

Notre Dame

Recent Results

Syracuse

Notre Dame

HEAD TO HEAD

Syracuse

Notre Dame

Syracuse

UPCOMING SCHEDULE

Notre Dame