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The upcoming Saturday football game on November 22, 2025, features a thrilling NCAAF matchup between the Nebraska Cornhuskers and Penn State Nittany Lions. This game at West Shore Home Field at Beaver Stadium in University Park, PA, promises exciting betting trends and game insights for bettors. Penn State enters as the favorite with an 8-point spread and a total points line set at 45. The Nittany Lions boast a stronger pass offense with 178.9 passing yards per game compared to Nebraska's 137.4, while Nebraska counters with a slightly better run offense at 137.4 rushing yards versus Penn State's 159.9. Penn State's pass defense allows 167.7 yards, while Nebraska's pass defense is slightly weaker at 134.6 yards allowed. The starting quarterbacks for both teams are expected to play, with Penn State's quarterback holding a slight edge in passing efficiency, giving them a strategic advantage in this outdoor game broadcasted on NBC.
Nebraska's recent performances show a resilient team with notable wins and losses, including a recent victory against UCLA Bruins with a 28-21 score. Penn State, despite some recent losses, maintains a competitive edge with a strong home record. The point spread and total points line provide valuable betting stats to inform your wagers. The best odds today for Penn State are -112 at Caesars, with Nebraska at +108, making the Nittany Lions a solid pick. For bettors looking to capitalize on these betting trends, Start your OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook to gain an edge.
In their last matchup on November 14, 2020, Nebraska won 30-23 against Penn State at Memorial Stadium in Lincoln, NE, a close game that can provide additional betting insights. Check out the Nebraska Cornhuskers and Penn State Nittany Lions ATS records and recent game stats on our NCAAF standings page to make smarter betting decisions.
![]() North Carolina State 5-544% +6 -108Caesars | |||||||
UNLV 8-241% -2 -129SugarHouse | |||||||
![]() #1Ohio State 10-030% -31½ -110FanDuel | |||||||
Army 5-436% -9½ -120FanDuel | |||||||
![]() Wake Forest 7-330% -17½ -110Caesars | |||||||
Virginia Tech 3-762% +18½ -113BetRivers | |||||||
![]() #8Oklahoma 8-234% -6½ -110Bet365 | |||||||
SMU 7-324% -2½ -110Bet365 | |||||||
![]() Iowa State 6-435% -3½ -108Caesars | |||||||
![]() Northwestern 5-539% -3½ -110BetMGM | |||||||
#3Texas A&M 10-0- -54½ -110Bet365 | |||||||
![]() #4Georgia 9-148% -43½ -110Bet365 | |||||||
![]() Georgia Southern 5-556% +12½ -115BetMGM | |||||||
![]() James Madison 9-131% -13½ -110Bet365 | |||||||
![]() Arizona 7-330% -6½ -120FanDuel | |||||||
![]() Toledo 6-487% -27½ -110Bet365 | |||||||
Wyoming 4-610% -6½ -112Caesars | |||||||
![]() Kennesaw State 7-322% -6½ -105FanDuel | |||||||
Auburn 4-6- -27½ -110Bet365 | |||||||
#10Alabama 8-2- -50½ -110FanDuel | |||||||
Appalachian State 4-664% +5½ -114Caesars | |||||||
![]() Florida Atlantic 4-688% +7½ -120FanDuel | |||||||
![]() UTEP 2-825% -3 -110Bet365 | |||||||
![]() Middle Tennessee 1-940% -6½ -113BetRivers | |||||||
![]() Louisiana Tech 5-530% +1½ -117SugarHouse | |||||||
UAB 3-772% +21½ -109Caesars | |||||||
![]() North Carolina 4-682% +7 -113Caesars | |||||||
![]() #17Texas 7-315% -8½ -110FanDuel | |||||||
![]() #7Oregon 9-146% -9½ -118SugarHouse | |||||||
Iowa 6-429% -16½ -110Bet365 | |||||||
![]() UTSA 5-581% +2½ -108Caesars | |||||||
![]() #14Vanderbilt 8-211% -8½ -110Caesars | |||||||
![]() South Alabama 3-754% +2½ -110FanDuel | |||||||
![]() Florida International 5-586% +1½ -120Caesars | |||||||
#9Notre Dame 8-267% -35 -110Bet365 | |||||||
Temple 5-578% +9½ -112Caesars | |||||||
UCF 4-623% -13 -110Caesars | |||||||
Maryland 4-673% +14 -107Caesars | |||||||
![]() #23Houston 8-243% -1 -114BetRivers | |||||||
![]() #12Utah 8-226% -17 -110Bet365 | |||||||
Troy 6-443% -10 -110BetMGM | |||||||
![]() South Carolina 3-730% -23½ -122FanDuel | |||||||
![]() Clemson 5-5- -41½ -110FanDuel | |||||||
Texas State 4-667% -18 -113BetRivers | |||||||
![]() #16Georgia Tech 9-18% -2½ -110Bet365 | |||||||
![]() Penn State 4-637% -8 -112Caesars | |||||||
![]() Boise State 6-40% -16½ -110Bet365 | |||||||
Air Force 3-792% +4 -118SugarHouse | |||||||
Florida 3-781% +4½ -115BetMGM | |||||||
Stanford 3-783% +3½ -114Caesars | |||||||
![]() Wisconsin 3-788% +8½ -110BetMGM | |||||||
Rice 5-580% +18½ -114BetRivers | |||||||
LSU 6-431% -21½ -110Bet365 | |||||||
![]() Cincinnati 7-386% +2½ -105Caesars | |||||||
![]() Colorado 3-787% +7½ -114FanDuel | |||||||
UCLA 3-785% +10½ -110Bet365 | |||||||
San Diego State 8-212% -12 -115SugarHouse | |||||||
![]() Fresno State 7-30% -2½ -115Bet365 | |||||||
![]() Ohio 7-442 -33½ -115BetRivers | |||||||
Bowling Green 3-816 -2½ -110Bet365 | |||||||
![]() Northern Illinois 3-819 +7½ -122FanDuel | |||||||
Buffalo 5-620 +2½ -107Caesars | |||||||
![]() Kent State 4-716 +8½ -115FanDuel | |||||||
Arkansas State 5-630 -2½ -110Bet365 |
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