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The upcoming Saturday football game on November 15, 2025, features the Notre Dame Fighting Irish visiting the Pittsburgh Panthers at Acrisure Stadium in Pittsburgh, PA. This NCAAF Week 12 matchup offers compelling betting trends, with Notre Dame favored by 12.5 points and an over/under set at 54 points, broadcast on ABC and ESPN networks.
Notre Dame's offense, led by their starting quarterback, boasts an impressive 271.7 passing yards and 194.4 rushing yards per game, while Pittsburgh's defense allows 237.4 passing yards and 80.9 rushing yards on average. Pittsburgh's offense counters with 302.9 passing yards and 124.4 rushing yards, facing a Notre Dame defense conceding 232.3 passing yards and 102.6 rushing yards. The Panthers' strong home record (4-1 ATS) contrasts with Notre Dame's 1-2 ATS away record, adding intrigue to the betting dynamics.
Notre Dame dominated their last encounter with Pittsburgh on October 28, 2023, winning 58-7, showcasing strong offensive and defensive play. The Panthers will look to leverage their home advantage this Saturday. Betting insights highlight the importance of the pass protection vs pass rush battle and the run game matchup, which could influence the final score significantly.
With Pittsburgh as underdogs at +12.5 and an over/under at 54, bettors should consider the potential for Notre Dame to cover the spread given their recent performances. The starting quarterbacks' health and performance will be pivotal, with both teams likely to start their primary QBs. For smart betting, check out the latest odds and consider starting your OddsTrader Turbo subscription to gain an edge. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
The best odds today for Pittsburgh are +12.5 at Caesars and for Notre Dame -12.5 at Caesars. In their last matchup on October 28, 2023, Notre Dame defeated Pittsburgh 58-7.
#20Louisville 7-229% -1½ -115BetMGM | |||||||
![]() #8Oregon 8-134% -24½ -115BetMGM | |||||||
![]() Connecticut 7-322% -7½ -105FanDuel | |||||||
![]() Charlotte 1-8100% +18½ -110FanDuel | |||||||
![]() #25Cincinnati 7-218% -6 -110Bet365 | |||||||
Navy 7-223% +10½ -114BetRivers | |||||||
![]() #2Indiana 10-016% -29 -112Caesars | |||||||
![]() #22Pittsburgh 7-270% +12½ -110Caesars | |||||||
Ball State 4-585% +2½ -106Caesars | |||||||
Oklahoma State 1-869% +20 -117SugarHouse | |||||||
#3Texas A&M 9-072% -17½ -110FanDuel | |||||||
![]() Northwestern 5-445% +11½ -115BetMGM | |||||||
LSU 5-419% -5 -110Caesars | |||||||
![]() Tulsa 2-740% +2½ -106FanDuel | |||||||
![]() Arizona State 6-312% -11 -114SugarHouse | |||||||
Kentucky 4-5- -21½ -110Bet365 | |||||||
Georgia State 1-876% +8 -112BetRivers | |||||||
UAB 3-678% +18½ -115FanDuel | |||||||
![]() New Mexico 6-317% -14 -115BetRivers | |||||||
![]() Missouri State 6-30% -4½ -105FanDuel | |||||||
![]() James Madison 8-170% -21 -109Caesars | |||||||
![]() Boston College 1-949% +17 -117SugarHouse | |||||||
![]() Duke 5-449% -4½ -110Caesars | |||||||
![]() #15Miami (FL) 7-26% -14½ -113BetRivers | |||||||
Michigan State 3-677% +7½ -114FanDuel | |||||||
#4Alabama 8-112% -5½ -113BetRivers | |||||||
Southern Miss 7-236% -3 -110BetMGM | |||||||
![]() #6Texas Tech 9-187% -23½ -110BetMGM | |||||||
![]() Louisiana-Monroe 3-667% +4½ -105FanDuel | |||||||
Illinois 6-318% -15 -113BetRivers | |||||||
#17USC 7-224% -6 -117SugarHouse | |||||||
![]() Western Kentucky 7-20% -13 -121SugarHouse | |||||||
![]() Nevada 1-892% +9½ +102Caesars | |||||||
East Carolina 6-373% -2½ -120SugarHouse | |||||||
Tulane 7-225% -17½ -110Caesars | |||||||
#23Tennessee 6-31% -39½ -110BetMGM | |||||||
![]() Wake Forest 6-342% -5½ -115BetRivers | |||||||
![]() Florida International 4-575% +3 -118BetRivers | |||||||
![]() Georgia Southern 4-540% -3 -114Caesars | |||||||
![]() Sam Houston State 1-885% +10½ -110Bet365 | |||||||
Baylor 5-482% +9 -114BetRivers | |||||||
![]() #7Ole Miss 9-118% -11½ -105BetMGM | |||||||
![]() Washington 6-39% -16½ -110Bet365 | |||||||
UNLV 7-212% -6 -110Bet365 | |||||||
![]() #5Georgia 8-168% -6 -110Bet365 | |||||||
Florida State 4-515% -13½ -115BetRivers | |||||||
![]() #1Ohio State 9-036% -31½ -105Bet365 | |||||||
![]() Missouri 6-327% -6½ -118FanDuel | |||||||
![]() Jacksonville State 6-375% +3½ -118FanDuel | |||||||
![]() Washington State 4-58% -7½ -115Bet365 | |||||||
#12Brigham Young 8-111% -3 -110Caesars | |||||||
![]() Fresno State 6-329% -3½ -105BetMGM | |||||||
San Diego State 7-237% -1½ -112FanDuel | |||||||
![]() Akron 4-735 -7 -118SugarHouse | |||||||
![]() Western Michigan 6-417 +2 -139SugarHouse | |||||||
![]() Massachusetts 0-103 +10 -110BetMGM | |||||||
Miami (OH) 5-53 +5½ -105Bet365 | |||||||
Central Michigan 6-438 -2½ -110BetMGM | |||||||
![]() Old Dominion 7-333 -9 -115BetRivers |
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