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Dec 21, 2025 4:05 PM EST
Week 16
ATL
-2½ (-110)o47½ (-115)
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Atlanta Falcons vs Arizona Cardinals Picks Week 16
Updated:Dec 16, 2025 1:45 AM EST
The upcoming NFL Week 16 showdown on December 21, 2025, between the Atlanta Falcons and the Arizona Cardinals at State Farm Stadium in Glendale, AZ, is shaping up to be a thrilling contest. Broadcast on FOX, this Sunday football game offers plenty of excitement for fans and bettors alike.
Our expert picks favor the Atlanta Falcons with a predicted score of 25 to 21 over the Arizona Cardinals. The Falcons are expected to cover the spread at -2.5, boasting a 54.5% hit rate and a positive EV of 2.1%. Conversely, the Cardinals at +2.5 hold a 45.5% hit rate but a negative EV, making the Falcons the smarter bet on the point spread market.
Additionally, the under 48 points total is recommended, with a 57.3% hit rate and a 4.9% EV, predicting a moderately low-scoring game with a combined total of around 46 points. Our predictions have been profitable in recent games, especially in the point spread market, where we have maintained a strong hit rate and EV, helping bettors make informed decisions.
For those looking to capitalize on this NFL action, our detailed picks and betting tips for the Falcons vs Cardinals game can be found on our NFL Week 16 picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
ATLSpread
CONSENSUS LINE
-2½ (-110)
PROJECTION
ARI (21) - ATL (25)
COVER PROBABILITY
EXPECTED VALUE
+2.1%
BET RATING
SEASON COVER %
7/14
50%
NFL
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NFLWeek 16
 Seattle 11-363% +1½ -120FanDuel | |||||||
 Washington 4-1076% +6½ -110Caesars | |||||||
 Chicago 10-429% +2 -118BetMGM | |||||||
 Cleveland 3-1195% +10½ -122FanDuel | |||||||
 New Orleans 4-10100% -4 -110Bet365 | |||||||
 N.Y. Giants 2-1271% +3 -110Caesars | |||||||
 Carolina 7-758% +3 -110FanDuel | |||||||
 Tennessee 2-1267% +3½ -108Caesars | |||||||
 Dallas 6-7-182% -1½ -115BetMGM | |||||||
 Miami 6-8100% +1½ -120Bet365 | |||||||
 Arizona 3-1143% +2½ -105Bet365 | |||||||
 Denver 12-247% -3 -108BetRivers | |||||||
 Detroit 8-611% -6½ -114FanDuel | |||||||
 Houston 9-511% -14½ -104FanDuel | |||||||
 Baltimore 7-748% -2½ -120BetRivers | |||||||
 Indianapolis 8-674% +6 -110Bet365 |
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