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The highly anticipated clash between the Arizona Cardinals and Indianapolis Colts is set to take place on October 12, 2025, at Lucas Oil Stadium in Indianapolis, IN. As we delve into the betting trends, it's essential to consider the Colts' formidable home record of 3-0, while the Cardinals have struggled on the road. The Colts, led by Daniel Jones, have shown a strong pass offense, averaging 253 passing yards per game, which could challenge the Cardinals' pass defense. However, the Cardinals' run offense, with an average of 118.2 rushing yards per game, might exploit the Colts' weaker run defense. The Cardinals, with Kyler Murray likely to play despite being listed as questionable, will need to step up their game to overcome the Colts' advantage. The point spread favors the Colts at -6.5, indicating a strong chance for a home victory, with the total points set at 47.5. Fans can catch this exciting matchup on FOX. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() N.Y. Giants 1-477% +7½ -110FanDuel | |||||||
![]() N.Y. Jets 0-584% +7½ -115Caesars | |||||||
![]() Pittsburgh 3-137% -5 -109BetRivers | |||||||
![]() Indianapolis 4-18% -6½ -105FanDuel | |||||||
![]() Baltimore 1-479% +7½ -109Caesars | |||||||
Jacksonville 4-10% +1½ -118Caesars | |||||||
Carolina 2-394% +3½ -112BetRivers | |||||||
Miami 1-488% +4½ -104FanDuel | |||||||
New Orleans 1-488% +3½ -105FanDuel | |||||||
![]() Las Vegas 1-431% -4½ -110Bet365 | |||||||
![]() Tampa Bay 4-124% -3 -105FanDuel | |||||||
Green Bay 2-1-112% -14½ -105BetMGM | |||||||
![]() Kansas City 2-3100% +1 -110BetMGM | |||||||
![]() Atlanta 2-291% +4 -112BetRivers | |||||||
![]() Washington 3-217% -4½ -105FanDuel |
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