Jacksonville Jaguars vs Arizona Cardinals Betting Trends

The upcoming NFL showdown on November 23, 2025, features the Jacksonville Jaguars visiting the Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Sunday football game promises intense action as both teams vie for a crucial regular-season win in Week 12 of the 2025-26 season. The game will be broadcast on CBS, making it accessible to fans and bettors nationwide.

Jacksonville Jaguars enter this matchup as slight favorites with a -2.5 point spread and odds of -141 at Caesars sportsbook, while the Cardinals are underdogs at +117. The total points line is set at 47.5, favoring the OVER. The Jaguars’ offense, led by starting quarterback Trevor Lawrence, boasts a solid 236.9 passing yards per game against a Cardinals defense that allows 221.4 passing yards. Arizona, however, counters with a versatile offense under backup quarterback Jacoby Brissett, as star Kyler Murray remains on injured reserve. Both teams have notable injury concerns, but Jacksonville’s lineup appears more intact heading into this clash.

Betting trends reveal the Cardinals have a 5-5 record against the spread (ATS) and a 1-4 home ATS record, while the Jaguars hold a 5-5 ATS overall and 1-3 on the road. The Cardinals’ defense excels in first downs by passing (12.4) and total yards (333.6 per game), but Jacksonville’s defense is competitive, especially in rushing defense, allowing only 86.7 rushing yards per game. The Jaguars' run offense averages 127.5 yards, which could test Arizona’s run defense ranked at 112.2 yards allowed.

Pass protection and pass rush battles will be key, with Arizona’s offensive line dealing with several questionable players like Will Hernandez and Kelvin Beachum, while Jacksonville has some key defensive players out. This game’s betting insights suggest a close contest where the Jaguars’ balanced offense and slight edge in quarterback play provide a betting advantage. The point spread of -2.5 favors Jacksonville, and the total of 47.5 points indicates potential scoring fireworks.

For those looking to make informed wagers, these betting trends and game insights are crucial. The teams’ recent performances and injury reports should guide your bets. The Cardinals and Jaguars faced off previously on September 26, 2021, where Arizona won 31-19. Check out that detailed encounter in our last matchup report for added context.

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