Carolina Panthers vs San Francisco 49ers Betting Trends

The Monday night football clash on November 24, 2025, between the Carolina Panthers and the San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling NFL regular-season showdown. This game offers valuable betting trends for sports bettors looking to capitalize on the matchup. The 49ers enter as favorites with a -7.5 point spread and a total points line set at 49.5, indicating expectations of a competitive game with solid scoring potential.

Carolina Panthers quarterback Bryce Young leads the offense, facing a tough San Francisco defense that ranks well in pass rush and pass defense. The Panthers' passing attack averages 187.2 yards, while the 49ers boast a stronger passing offense with 254.5 yards per game. The 49ers' defense allows just 103.8 rushing yards per game, and their pass rush has recorded 103.8 sacks yards, posing a challenge to Carolina's offensive line, especially with key injuries to Panthers guards Cade Mays (out) and Robert Hunt (IR).

San Francisco's starting QB Brock Purdy will look to exploit the Panthers' defense, which allows 113 rushing yards per game and has a moderate pass defense. The 49ers have a balanced offensive attack with 349 total yards per game compared to Carolina's 314.3 yards. Recent form favors the Panthers slightly, with Carolina winning 4 of their last 5 games, while San Francisco has a mixed record with 5 wins and 5 losses in their last 10.

The Panthers are underdogs at +7.5 with odds of +290 at Caesars, while the 49ers are favorites at -7.5 and -380 odds. The total points line at 49.5 suggests a potentially high-scoring game, supported by both teams' recent games often going over the total. This matchup offers intriguing betting insights, especially considering the quarterback advantage, pass protection, and defensive strengths.

For those looking to bet smarter, Start your OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook to gain an edge. The game will be broadcast on ESPN, providing excellent Sunday night football viewing. Check out the detailed betting trends and past performance, including their last matchup on October 9, 2022, where the 49ers won 37-15 for more context.