Buffalo Bills vs Denver Broncos Odds for NFL Showdown

The highly anticipated NFL matchup between the Buffalo Bills and Denver Broncos is scheduled for January 17, 2026, at Empower Field at Mile High in Denver, CO. This Saturday football game promises intense action as the Broncos host the Bills in a battle that will captivate fans nationwide. The game will be broadcast on CBS, making it accessible for viewers across the country.

Current odds favor the Buffalo Bills with a point spread of -1½ -110, while the Denver Broncos stand at +1½ -110, according to BetOnline. These odds have shifted slightly from the opening lines, indicating growing confidence in the Bills' ability to secure a win on the road. The total points line is set at 46½ with -110 odds for both over and under bets, suggesting a moderately high-scoring affair.

Understanding these betting lines is crucial for making informed wagers. The point spread reflects the expected margin of victory, while the totals provide insight into the game's pace and scoring potential. Bettors should consider the Bills' strong performance and the Broncos' home-field advantage when placing their bets.

For comprehensive analysis and the latest odds, visit our NFL odds page. To find the best sportsbook to place your bets, check out our detailed reviews at BetOnline sportsbook review. Stay ahead of the game with expert insights and capitalize on the shifting odds to make smart betting decisions.